To get the most benefit we recommend taking two capsules of Glutatione Forte a day.

In particular:

• Mid-morning, away from meals: one capsule of Glutatione Forte
• Mid-afternoon, away from meals: one capsule of Glutatione Forte

Glutatione Forte comes in acid-resistant capsules: for this reason we recommend taking it at least two hours away from your main meals.

Length of the course with Glutatione Forte

You will already notice the benefits after the first few doses.

We recommend carrying on with the course for three months to stabilise the results achieved.

At the end of the treatment give us a call! We are interested in you and we want to know how you got on. Together with our experts you will work out how to approach the following period so as to maintain the results obtained!

On its own the Glutatione Forte formula already gives you excellent results. If you want to make its action even more complete you can combine it with the formulas of:

• Epasal, to purify the liver and, in general, the body;
• Pausanorm Forte, for the wellbeing of women in menopause, in particular for the skin;
• DKE + Magnesio: to support the immune defences and supplement natural vitamin D;
• Sanaos New Formula, to keep joints and ligaments young and strong;
• Kiomasal, for the beauty of skin, hair and nails;
• Sport 1 Endurance and Sport 2 Recupero, to support sports activity at every stage;
• Organic Goji Juice or Organic Maqui: to increase the supply of antioxidants.

Warnings

Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of the reach of children under 3 years of age. Do not exceed the recommended daily dose. The expiry date shown refers to the product when intact and stored in a cool, dry place, away from sources of light and heat.

Caper (Capparis spinosa L.) fruit dry extract titrated 50% quercetin, reduced L-Glutathione obtained by bio-fermentation (23.3%), Acid-resistant capsule (coating agent: hydroxypropylmethylcellulose; gelling agent: gellan gum), Chinotto (Citrus myrtifolia Raf.) fruit dry extract titrated 40% naringin, OxiP® (Vaccinium myrtillus L. fruit, Gynostemma pentaphyllum (Thunb.) Makino herb, Scutellaria baicalensis Georgi root, Fallopia japonica (Houtt.) Ronse Dec. root) dry extract titrated 1% anthocyanins - 1% gypenosides - 1% baicalin - 0.7% resveratrol, Selenium L-Methionine, Silica from Bamboo sprouts; Anti-caking agents: vegetable magnesium stearate. Dry extracts are supported on maltodextrins, acacia fiber, and rice proteins.

Nutritional Values

*100% RNV

Glutatione Forte was created out of the need to bring to market an innovative product that combined, for the very first time, Reduced Glutathione, Quercetin (at the maximum daily intakes) and Naringenin. A truly innovative supplement on the market!

Every component of Glutatione Forte comes from biofermentation and 100% natural sources and not from a laboratory, as is the case with most products on the market.

It also provides Selenium and OxiP®, a registered mix of active ingredients with a powerful antioxidant action.

Finally, Glutatione Forte comes in acid-resistant capsules.

Using this type of capsule makes it possible to guarantee complete protection of GSH from gastric degradation, thus ensuring its maximum availability for absorption and function.

Experimental Phytotherapy

Reduced Glutathione

• Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J Pharmacol Exp Ther. 2001 Mar;296(3):996-1005. PMID: 11181934.

In this study, researchers focused on the anti-inflammatory properties of glutathione towards the pulmonary alveoli. To do so, they cultured an in vitro model of alveolar epithelial cells and altered them with pro-inflammatory cytokines. They then introduced reduced glutathione, observing that this substance reduces the production and release of pro-inflammatory cytokines. The researchers suggest that these positive results may also apply to the in vivo treatment of pulmonary disorders

• Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 Jul 10;6(7):1558-1562. doi: 10.1021/acsinfecdis.0c00288. Epub 2020 May 28. PMID: 32463221; PMCID: PMC7263077.

This study assessed glutathione deficiency in relation to the most severe manifestations in patients with Covid-19 and went on to show how the use of glutathione may be a means for the treatment (under medical supervision) and prevention of COVID-19 disease.

• Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55. doi: 10.2174/092986706777452542. PMID: 16787218.

In this review, researchers highlighted how glutathione deficiency is the lowest common denominator of several diseases, viral infections and immune dysfunctions. Conversely, supplementation with Reduced Glutathione has proved useful in inhibiting viral replication, inhibiting the production of pro-inflammatory cytokines and supporting the treatment of allergies.

Quercetin

• Oxid Med Cell Longev. 2016. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Costa LG, Garrick JM, Roquè PJ, Pellacani C.
• Molecules. 2019 Mar 21. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Xu D, Hu MJ, Wang YQ, Cui YL.

These studies have shown how Quercetin: acts as a scavenger of radicals of oxygen and nitrogen, meaning it can transform these species into non-radical compounds devoid of toxicity; activates the transcription factor Nrf2, which promotes the expression of a wide range of antioxidant genes; increases the expression of PON2, an enzyme that protects cells from oxidative damage; induces the synthesis of glutathione, a powerful antioxidant; and increases the expression of antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase and haem oxygenase.

• Nutrients 2016 Mar 15. Quercetin, Inflammation and Immunity. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y.

In this study, researchers showed that quercetin is a cofactor of many intracellular signalling kinases, phosphatases, enzymes and membrane proteins; it also possesses powerful anti-inflammatory and immune-stimulating properties.

Naringenin

• Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease. Testai L, Calderone V. Nutrients. 2017 May 16;9(5). Review.

In this review, researchers summarised the research linking naringenin to the incidence of cardiovascular disease. In particular, the various epidemiological studies have shown that fruits of the Citrus genus significantly reduce the incidence of cardiovascular disease risk.

• Da Pozzo E, Costa B, Cavallini C, Testai L, Martelli A, Calderone V, Martini C. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxid Med Cell Longev. 2017;2017:9536148. doi: 10.1155/2017/9536148. Epub 2017 Mar 12. PMID: 28386313; PMCID: PMC5366223.

In this study, researchers showed that naringenin has protective properties against cardiometabolic disorders. In particular, the results suggested that naringenin has beneficial, protective anti-ageing effects on myocardial cells.

• Zeng W, Jin L, Zhang F, Zhang C, Liang W. Naringenin as a potential immunomodulator in therapeutics. Pharmacol Res. 2018 Sep;135:122-126. doi: 10.1016/j.phrs.2018.08.002. Epub 2018 Aug 3. PMID: 30081177.

In this study, researchers focused on naringenin's ability to inhibit the inflammatory response in different cell types. According to the scientists, this property is due to naringenin's ability to suppress the production of inflammatory cytokines at a much deeper level than other compounds such as curcumin and apigenin. This is why, the researchers suggest, naringenin is useful as an immunomodulator and in the treatment of related inflammatory diseases.

OxiP®

Bilberry

• Lietti A, Cristoni A, Picci M. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittelforschung. 1976;26(5):829-32. PMID: 9100.

In this study, carried out on animals, researchers highlighted the marked anti-inflammatory and antioxidant properties of Bilberry, useful for supporting the proper function of many of the body's systems and structures.

Gynostemma pentaphyllum

• Song N, Jia L, Cao H, Ma Y, Chen N, Chen S, Lv X, Yang G. Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway. Biomed Res Int. 2020 Jun 20;2020:2819658. doi: 10.1155/2020/2819658. PMID: 32685460; PMCID: PMC7327587.

In this study, researchers examined the relationship between Gynostemma and atherosclerosis, today one of the most frequent causes of disease and death in the world. In atherosclerosis, the degradation of endothelial cells is, unfortunately, a major component of the disease. Damage to these cells has cascading impacts on many aspects of vascular function. The research highlighted how Gynostemma can modulate mitochondrial function and consequently enhance endothelial protection.

Scutellaria

• Liao H, Ye J, Gao L, Liu Y. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. Biomed Pharmacother. 2021 Jan;133:110917. doi: 10.1016/j.biopha.2020.110917. Epub 2020 Nov 17. PMID: 33217688.

In this review of various studies, researchers focused on the ability of Scutellaria to relieve the discomfort caused by inflammatory cytokines, showing normalising effects on inflammatory events.

Fallopia

• Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8. doi: 10.1210/jc.2010-0482. Epub 2010 Jun 9. PMID: 20534755; PMCID: PMC2936054.

In this study, researchers analysed the link between resveratrol, the active ingredient of Fallopia, and oxidative stress and inflammation. In detail, the resveratrol extract led to a significant reduction in inflammation levels and proved useful in protecting cells from oxidative damage.

• Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab. 2011 May;96(5):1409-14. doi: 10.1210/jc.2010-1812. Epub 2011 Feb 2. PMID: 21289251; PMCID: PMC3085195.

In this study, researchers highlighted how resveratrol is useful in counteracting inflammation caused by oxidative stress following meals rich in fats and carbohydrates.

Selenium

• Kiremidjian-Schumacher L, Roy M. - Selenium and immune function. Z Ernahrungswiss. 1998;37 Suppl 1:50-6. PMID: 9558729.

This research relates Selenium to the functions of the immune system. The study was carried out on volunteers and, at the end of the treatment, improvements were seen in the response of immune cells and therefore in the body's defences in general.

Bibliography

¹ Thiel RJ. Natural vitamins may be superior to synthetic ones. Med Hypotheses. 2000 Dec;55(6):461-9. doi: 10.1054/mehy.2000.1090. PMID: 11090291.

² Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004 Dec 16;432(7019):829-37. doi: 10.1038/nature03194. PMID: 15602548.

³ Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12.

⁴ Al-Gubory KH. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reprod Biomed Online. 2014 Jul;29(1):17-31. doi: 10.1016/j.rbmo.2014.03.002. Epub 2014 Mar 21. PMID: 24813750.

⁵Redford, K.E., Abbott, G.W. The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Commun Biol 3, 356 (2020). https://doi.org/10.1038/s42003-020-1089-8.

⁶ Wang Z, Wang Y, Zhang J, Feng G, Miao S, Lu R, Tian X, Ye Y. Antioxidant Intervention Against Microplastic Hazards. Antioxidants (Basel). 2025 Jun 27;14(7):797. doi: 10.3390/antiox14070797. PMID: 40722901; PMCID: PMC12291741.

Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

Italian Ministry of Health code: 148940