To get maximum benefits, we recommend that you take two capsules of Glutatione Forte per day.

Please follow the instructions hereunder:

• mid-morning, preferably on an empty stomach: 1 capsule of Glutatione Forte,
• mid-afternoon, preferably on an empty stomach: 1 capsule of Glutatione Forte.

Glutatione Forte Nuova Formula comes in acid-resistant capsules. That is why we advise you to take the capsules away from meals (at least 2 hours, before or after).

Duration of treatment with Glutatione Forte, a natural supplement providing Glutathione, Quercetin and Naringenin.

After a short time, you will see the results and feel the benefits. We recommend that you continue the treatment for at least three months to achieve the best results and keep them over time.

At the end of the treatment contact us! We care for you and would be most pleased to know how you got on with the treatment and how you feel. Our Team of experts (Biologists and Naturopathic Doctors) will be happy to help you take the next steps to maintain over time the results you have achieved.

Taken alone, Glutatione Forte gives you excellent results. Nonetheless, for a stronger action, you may want to combine it with other formulae, such as:

• Salugea Epasal, to cleanse the liver and, in general, the whole body;
• Salugea Pausanorm Forte, for the well-being of women in menopause and for a glowing and toned skin;
• Salugea DKE + Magnesio, to support immune defenses through the intake of natural Vitamin D;
• Salugea Sanaos Nuova Formula, to keep joints and ligaments young and strong;
• Salugea Kiomasal, for the beauty of your hair, skin and nails;
• Salugea Sport 1 Endurance and Sport 2 Recupero, to support you in every stage of your training or general physical activity;
• Salugea Organic Goji Juice or Maqui Juice, to increase your daily intake of antioxidants.

Warnings

Supplements cannot be considered as a replacement for healthy diet and lifestyle. Keep out of reach of children under the age of three. Do not exceed the recommended daily dosage. The expiry date refers to the product intact, stored in a cool and dry place, away from heat and direct sunlight.

Caper (Capparis spinosa L.) fruit dry extract titrated 50% quercetin, reduced L-Glutathione obtained by bio-fermentation (23.3%), Acid-resistant capsule (coating agent: hydroxypropylmethylcellulose; gelling agent: gellan gum), Chinotto (Citrus myrtifolia Raf.) fruit dry extract titrated 40% naringin, OxiP® (Vaccinium myrtillus L. fruit, Gynostemma pentaphyllum (Thunb.) Makino herb, Scutellaria baicalensis Georgi root, Fallopia japonica (Houtt.) Ronse Dec. root) dry extract titrated 1% anthocyanins - 1% gypenosides - 1% baicalin - 0.7% resveratrol, Selenium L-Methionine, Silica from Bamboo sprouts; Anti-caking agents: vegetable magnesium stearate. Dry extracts are supported on maltodextrins, acacia fiber, and rice proteins.

Nutritional Values

*100% RNV

In the next paragraph, will you find more in-depth information from several scientific studies.

Before we leave you to the next section, we shall remind you of the following main points.

• Glutatione Forte was developed to satisfy the market need for an innovative product, containing - the first time ever - a combination of Reduced Glutathione, Quercetin (at the maximum allowed daily intake) and Naringenin. A true innovation! The formula of Glutatione Forte is exclusive, no other natural food supplement on the market has the same active ingredients.
• Every ingredient in Glutatione Forte comes from bio-fermentation and from 100% natural sources, with no synthetic (made in a laboratory) ingredients, which is instead the case with most of the products on the market.
• Glutatione Forte also provides Selenium and OxiP®, a patented mix of active ingredients with a powerful antioxidative action.
• Finally, Glutatione Forte comes in acid-resistant capsules. By using this type of capsule, it is possible to ensure complete protection of GSH from gastric degradation, thereby maximizing its availability for absorption and functionality.

Experimental Phytotherapy

Reduced Glutathione

• Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J Pharmacol Exp Ther. 2001 Mar;296(3):996-1005. PMID: 11181934.

In this study, researchers have focused on the anti-inflammatory action of glutathione on the pulmonary alveoli. An in vitro model of alveolar epithelial cells was developed and altered by means of pro-inflammatory cytokines. Then, Reduced Glutathione was added with the result that it reduced the production and release of pro-inflammatory cytokines. Researchers suggest that such evidence confirms that glutathione can be useful in the treatment of pulmonary disorders.

• Polonikov A. Endogenous Deficiency of Glutatione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 Jul 10;6(7):1558-1562. doi: 10.1021/acsinfecdis.0c00288. Epub 2020 May 28. PMID: 32463221; PMCID: PMC7263077.

Researchers observed that reduced glutathione deficiency was a crucial factor in the most severe cases of the Covid-19 disease. The study confirms that the administration of reduced glutathione (under medical supervision) could be an effective therapy and a prevention tool in case of COVID-19 disease.

• Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55. doi: 10.2174/092986706777452542. PMID: 16787218.

In this review, researchers confirm that reduced Glutathione deficiency is the common denominator of several diseases, viral infections and immune-system dysfunctions. According to the study, Reduced Glutathione supplementation has the capacity to inhibit viral replication and the action of pro-inflammatory cytokines and could be useful to treat allergic disorders.

Quercetin

• Oxid Med Cell Longev. 2016. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Costa LG, Garrick JM, Roquè PJ, Pellacani C.
• 2019 Mar 21. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Xu D, Hu MJ, Wang YQ, Cui YL.

The study confirms the action of Quercetin as an oxygen and nitrogen radical scavenger, which means that it transforms these oxygen reactive species into non-radical compounds with no toxicity. The transcription factor Nrf2 - which promotes the expression of a wide range of antioxidant genes - is activated. The expression of PON2 - an enzyme that protects cells from oxidative damage - is increased. Besides, the synthesis of glutathione, a powerful antioxidant, is induced. And finally, the expression of antioxidant enzymes - including superoxide dismutase, catalase, glutathione peroxidase, and heme oxygenase - is also increased.

• 2016 Mar 15. Quercetin, Inflammation and Immunity. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y.

The study demonstrates that quercetin is a cofactor for many intracellular signal-related kinases, phosphatases, enzymes, and membrane proteins. It also has a strong anti-inflammatory and immuno-stimulating action.

Naringenin

• Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease. Testai L, Calderone V. Nutrients. 2017 May 16;9(5). Review.

The review collects the results of a number of studies made on naringenin and the incidence of cardiovascular diseases. Various epidemiological studies confirm that citrus fruits significantly reduce the incidence of cardiovascular disease risks.

• Da Pozzo E, Costa B, Cavallini C, Testai L, Martelli A, Calderone V, Martini C. The Citrus Flavanone Naringenin Protects Myocardial Cells Against Age-Associated Damage. Oxid Med Cell Longev. 2017;2017:9536148. doi: 10.1155/2017/9536148. Epub 2017 Mar 12. PMID: 28386313; PMCID: PMC5366223.

The study highlights naringenin protective properties against cardio-metabolic disorders. Particularly, results suggest that naringenin has beneficial and protective anti-aging effects on myocardial cells.

• Zeng W, Jin L, Zhang F, Zhang C, Liang W. Naringenin as a potential immunomodulator in therapeutics. Pharmacol Res. 2018 Sep;135:122-126. doi: 10.1016/j.phrs.2018.08.002. Epub 2018 Aug 3. PMID: 30081177.

In this study, researchers focused on naringenin ability to inhibit the inflammatory response in different cell types. According to scientists, this property is due to naringenin's ability to suppress the production of inflammatory cytokines at a much deeper level than other components such as curcumin and apigenin. That's why, researchers suggest that naringenin can be useful as an immunomodulator and in the treatment of inflammatory diseases.

OxiP®

Bilberry

• Lietti A, Cristoni A, Picci M. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and anti-inflammatory activity. Arzneimittelforschung. 1976;26(5):829-32. PMID: 9100.

The study, carried out on animals, highlights the strong anti-inflammatory and antioxidant properties of Bilberry, which promotes the proper functioning of many apparatuses and organic structures.

Gynostemma pentafillum

• Song N, Jia L, Cao H, Ma Y, Chen N, Chen S, Lv X, Yang G. Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway. Biomed Res Int. 2020 Jun 20;2020:2819658. doi: 10.1155/2020/2819658. PMID: 32685460; PMCID: PMC7327587.

Researchers investigated the effects of Gynostemma on atherosclerosis, which is today one of the most frequent causes for disease and death worldwide. Atherosclerosis entails a degradation of endothelial cells, a main disease-related factor. Such degradation deeply affects the vascular function, under many aspects. Research shoes that Gynostemma modulates the mitochondrial function and, as a consequence, it strengthens endothelial protection.

Scutellaria

• Liao H, Ye J, Gao L, Liu Y. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. Biomed Pharmacother. 2021 Jan;133:110917. doi: 10.1016/j.biopha.2020.110917. Epub 2020 Nov 17. PMID: 33217688.

In this review of various studies, researchers focused on the ability of Scutellaria to alleviate infection-related cytokine storms, acting as an immunomodulator, regulating inflammatory responses.

Fallopia

• Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8. doi: 10.1210/jc.2010-0482. Epub 2010 Jun 9. PMID: 20534755; PMCID: PMC2936054.

In this study, researchers investigated the link between resveratrol, Fallopia active principle, in relation to oxidative stress and inflammation. The extract induced a significant reduction in reactive oxygen species generation, showing a comprehensive suppressive effect on oxidative and inflammatory stress. Hence, resveratrol protects cells from oxidative damage.

• Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab. 2011 May;96(5):1409-14. doi: 10.1210/jc.2010-1812. Epub 2011 Feb 2. PMID: 21289251; PMCID: PMC3085195.

The study confirms that resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress, due to an unbalanced diet high in fats and carbohydrates.

Selenium

• Kiremidjian-Schumacher L, Roy M. - Selenium and immune function. Z Ernahrungswiss. 1998;37 Suppl 1:50-6. PMID: 9558729.

This research investigates the effects of Selenium on the immune system. The study was carried out on healthy volunteers. Supplementation with Selenium resulted in a significant increase of the capacity of lymphocytes to respond to stimulation, thus improving the immune system response in general.

DISCLAIMER The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition.

Bibliography

1 Thiel RJ. Natural vitamins may be superior to synthetic ones. Med Hypotheses. 2000 Dec;55(6):461-9. doi: 10.1054/mehy.2000.1090. PMID: 11090291.

2 Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004 Dec 16;432(7019):829-37. doi: 10.1038/nature03194. PMID: 15602548.

3 Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12.

4 Redford, K.E., Abbott, G.W. The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Commun Biol 3, 356 (2020). https://doi.org/10.1038/s42003-020-1089-8.

I nostri testi hanno scopo divulgativo, non vanno intesi come indicazione di diagnosi e cura di stati patologici e non vogliono sostituirsi in alcun modo al parere del Medico.

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