Glutatione Forte was created to bring to market an innovative product that would combine, for the very first time, Reduced Glutathione, Quercetin (at the maximum daily intake) and Naringenin. A truly innovative supplement on the market!
Every component of Glutatione Forte comes from biofermentation and 100% natural sources, and not from a laboratory, as is the case with most products on the market.
It also provides Selenium and OxiP®, a registered blend of active ingredients with a powerful antioxidant action.
Lastly, Glutatione Forte comes in acid-resistant capsules.
Using this type of capsule ensures complete protection of GSH from breakdown in the stomach, so that it is as available as possible for absorption and to perform its function.
Experimental Phytotherapy
Reduced Glutathione
- Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J Pharmacol Exp Ther. 2001 Mar;296(3):996-1005. PMID: 11181934.
In this study, the researchers focused on the anti-inflammatory properties of glutathione in the pulmonary alveoli. To do this, they grew an in vitro model of alveolar epithelial cells and challenged them with pro-inflammatory cytokines. They then introduced reduced glutathione and observed that it reduces the production and release of pro-inflammatory cytokines. The researchers suggest that these positive results could also apply to the in vivo treatment of lung disorders.
- Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020 Jul 10;6(7):1558-1562. doi: 10.1021/acsinfecdis.0c00288. Epub 2020 May 28. PMID: 32463221; PMCID: PMC7263077.
This study assessed glutathione deficiency in relation to the most severe manifestations in patients with COVID-19 and went on to show how the use of glutathione could be a means of treating (under medical supervision) and preventing COVID-19.
- Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55. doi: 10.2174/092986706777452542. PMID: 16787218.
In this review, the researchers highlighted how glutathione deficiency is the common denominator of various diseases, viral infections and immune dysfunctions. Conversely, Reduced Glutathione intake has proved useful in inhibiting viral replication, inhibiting the production of pro-inflammatory cytokines and supporting the treatment of allergies.
Quercetin
- Oxid Med Cell Longev. 2016. Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Costa LG, Garrick JM, Roquè PJ, Pellacani C.
- Molecules. 2019 Mar 21. Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Xu D, Hu MJ, Wang YQ, Cui YL.
These studies showed that Quercetin: acts as a scavenger of radicals derived from oxygen and nitrogen, i.e. it is able to convert these species into non-radical compounds that are free of toxicity; activates the transcription factor Nrf2, which promotes the expression of a wide range of antioxidant genes; increases the expression of PON2, an enzyme that protects cells from oxidative damage; induces the synthesis of glutathione, a powerful antioxidant; increases the expression of antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and haem oxygenase.
- Nutrients 2016 Mar 15. Quercetin, Inflammation and Immunity. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y.
In this study, the researchers showed that quercetin is a cofactor of many intracellular signalling kinases, phosphatases, enzymes and membrane proteins, and that it also has powerful anti-inflammatory and immunostimulant properties.
Naringenin
- Nutraceutical Value of Citrus Flavanones and Their Implications in Cardiovascular Disease. Testai L, Calderone V. Nutrients. 2017 May 16;9(5). Review.
In this review, the researchers summarised the research linking naringenin to the incidence of cardiovascular disease. In particular, the various epidemiological studies showed that fruits of the genus Citrus significantly reduce the risk of cardiovascular disease.
- Da Pozzo E, Costa B, Cavallini C, Testai L, Martelli A, Calderone V, Martini C. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxid Med Cell Longev. 2017;2017:9536148. doi: 10.1155/2017/9536148. Epub 2017 Mar 12. PMID: 28386313; PMCID: PMC5366223.
In this study, the researchers showed that naringenin has protective properties against cardiometabolic disorders. In particular, the results suggested that naringenin has beneficial and protective anti-ageing effects on myocardial cells.
- Zeng W, Jin L, Zhang F, Zhang C, Liang W. Naringenin as a potential immunomodulator in therapeutics. Pharmacol Res. 2018 Sep;135:122-126. doi: 10.1016/j.phrs.2018.08.002. Epub 2018 Aug 3. PMID: 30081177.
In this study, the researchers focused on naringenin’s ability to inhibit the inflammatory response in different types of cells. According to the scientists, this property is due to naringenin’s ability to suppress the production of inflammatory cytokines at a much deeper level than other compounds such as curcumin and apigenin. This is why, the researchers suggest, naringenin is useful as an immunomodulator and in the treatment of related inflammatory diseases.
OxiP®
Bilberry
- Lietti A, Cristoni A, Picci M. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittelforschung. 1976;26(5):829-32. PMID: 9100.
In this animal study, the researchers highlighted the marked anti-inflammatory and antioxidant properties of Bilberry, which help support the proper functioning of many of the body’s systems and structures.
Gynostemma pentaphyllum
- Song N, Jia L, Cao H, Ma Y, Chen N, Chen S, Lv X, Yang G. Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway. Biomed Res Int. 2020 Jun 20;2020:2819658. doi: 10.1155/2020/2819658. PMID: 32685460; PMCID: PMC7327587.
In this study, the researchers looked at Gynostemma in relation to atherosclerosis, currently one of the most frequent causes of illness and death worldwide. In atherosclerosis, the deterioration of endothelial cells is, unfortunately, an important component of the disease. Damage to these cells has knock-on effects on many aspects of vascular function. The research showed that Gynostemma is able to modulate mitochondrial function and consequently enhance endothelial protection.
Scutellaria
- Liao H, Ye J, Gao L, Liu Y. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. Biomed Pharmacother. 2021 Jan;133:110917. doi: 10.1016/j.biopha.2020.110917. Epub 2020 Nov 17. PMID: 33217688.
In this review of various studies, the researchers focused on Scutellaria’s ability to relieve the discomfort caused by inflammatory cytokines, showing a normalising effect on inflammatory events.
Fallopia
- Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8. doi: 10.1210/jc.2010-0482. Epub 2010 Jun 9. PMID: 20534755; PMCID: PMC2936054.
In this study, the researchers analysed the link between resveratrol, the active ingredient of Fallopia, and oxidative stress and inflammation. Specifically, the resveratrol extract led to a significant reduction in inflammation levels and proved useful in protecting cells from oxidative damage.
- Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab. 2011 May;96(5):1409-14. doi: 10.1210/jc.2010-1812. Epub 2011 Feb 2. PMID: 21289251; PMCID: PMC3085195.
In this study, the researchers showed that resveratrol helps counteract inflammation caused by oxidative stress following meals rich in fats and carbohydrates.
Selenium
- Kiremidjian-Schumacher L, Roy M. - Selenium and immune function. Z Ernahrungswiss. 1998;37 Suppl 1:50-6. PMID: 9558729.
This research looks at the relationship between Selenium and immune system function. The study was carried out on volunteers, and at the end of the treatment there were improvements in the response of immune cells and therefore in the body’s defences in general.
Bibliography
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Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.