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DKE + Magnesio Salugea
DKE + Magnesio capsule held between the fingers
features of DKE + Magnesio: vegetable capsules, suitable for vegans and vegetarians, gluten- and lactose-free, GMO-free, no synthetic preservatives or additives, dark glass bottle
what you get with DKE + Magnesio: vitamins D and K for bones and teeth, vitamin D for calcium absorption and the immune system, vitamin D and magnesium for muscle function, vitamin E for protection from oxidative stress
DKE + Magnesio ingredients: vitamin D3, vitamin K2, vitamin E and magnesium citrate
why Salugea: comparison between DKE + Magnesio and standard supplements (vegetable capsules, dark glass bottle, natural ingredients, reusable safety seal)
how to use the safety seal under the cap of the DKE + Magnesio bottle: open, remove the seal, place it back in the cap with the silver side facing up and close again
smiling couple outdoors and DKE + Magnesio pack, with vitamin D, vitamin K and other natural ingredients for bone and tooth wellbeing
DKE + Magnesio Salugea label
3 packs of the DKE + Magnesio supplement
6 packs of the DKE + Magnesio supplement
DKE + Magnesio SalugeaDKE + Magnesio capsule held between the fingersfeatures of DKE + Magnesio: vegetable capsules, suitable for vegans and vegetarians, gluten- and lactose-free, GMO-free, no synthetic preservatives or additives, dark glass bottlewhat you get with DKE + Magnesio: vitamins D and K for bones and teeth, vitamin D for calcium absorption and the immune system, vitamin D and magnesium for muscle function, vitamin E for protection from oxidative stressDKE + Magnesio ingredients: vitamin D3, vitamin K2, vitamin E and magnesium citratewhy Salugea: comparison between DKE + Magnesio and standard supplements (vegetable capsules, dark glass bottle, natural ingredients, reusable safety seal)how to use the safety seal under the cap of the DKE + Magnesio bottle: open, remove the seal, place it back in the cap with the silver side facing up and close againsmiling couple outdoors and DKE + Magnesio pack, with vitamin D, vitamin K and other natural ingredients for bone and tooth wellbeingDKE + Magnesio Salugea label3 packs of the DKE + Magnesio supplement6 packs of the DKE + Magnesio supplement
Vitamins D, K, E plus Magnesium

DKE + Magnesio

Contenuto: 60 vegetable capsules

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"I am very satisfied with this supplement because my vitamin D blood test values are perfect." - Viviana

With Vitamin D3, K2 and Magnesium, which contribute to the maintenance of normal bones. Vitamin D also contributes to the normal function of the immune system.

€ 34,32 € 42,90
Abbonati e risparmia: 25% di sconto

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Vitamin D, K, E and Magnesium Supplement

DKE + Magnesio by Salugea is a 100% natural supplement that combines Vitamin D3, Vitamin K2, Vitamin E and Magnesium in one single product. It helps support the immune defences and the wellbeing of bones and teeth.

The strength of DKE + Magnesio lies in its 100% natural formulation based on Vitamin D3 extracted from Lichen, Vitamin K2 extracted from fermented chickpea flour, Vitamin E from sunflower seed oil and Magnesium citrate.

Who is DKE + Magnesio for?

DKE + Magnesio is suitable for those who:

  • spend their days indoors with little exposure to sunlight,
  • want to support the structure of their bones and teeth in a natural way,
  • want to support their immune system,
  • are menopausal women wishing to prevent osteopenia and osteoporosis,
  • want to promote their resistance to stress, or need Magnesium to combat tiredness,
  • are looking for a powerful anti-ageing supplement,
  • are elderly people who want to help their bones maintain their density.

The benefits you get from DKE + Magnesio

Thanks to the active ingredients of DKE + Magnesio, you will:

  1. Promote bone wellbeing over time. The combination of vitamins D, K, E and Magnesium contributes to maintaining bone density and, above all, prevents the loss of calcium by directing it to the bones and teeth.
  2. Strengthen your immune system. Vitamin D has a direct effect on the immune system, as it supports it and allows the body to cope better with the colder seasons.
  3. Support your skeletal system during menopause. During this period (generally from the age of 45 onwards), oestrogen and progesterone levels gradually decline. One of the most common consequences is a reduction in bone mass. In addition, the increase in blood lipids (also caused by the decline in these two classes of hormones) makes it increasingly difficult for calcium to bind to bone tissue. This is why it is extremely important for women approaching this delicate stage of their lives to follow a course of vitamin D3 supplementation with DKE + Magnesio.
  4. Support the cardiovascular system. Those who wish to act positively on the likelihood of cardiovascular calcification, especially in the large vessels, can combine it with a treatment to control blood lipid levels in order to reduce the risk of atherosclerosis.

Why is DKE + Magnesio different from other Vitamin D supplements?

  • It comes in pharmaceutical-grade dark glass bottles. Glass is the only material that can guarantee the quality and safety of the product over time, as well as being good for the environment!
  • It is 100% natural.
  • Its active ingredients are beneficial for both the bones and the immune defences.
  • It comes in vegetable capsules that can be opened.
  • It is suitable for both vegans and vegetarians.
  • It is gluten-free.

How DKE + Magnesio works

Vitamin D3

Vitamin D is important for both cellular metabolism and immune function, as it regulates calcium homeostasis and modulates the response of both the innate and adaptive immune systems¹.

With sufficient exposure to UV-B rays, humans can endogenously synthesise vitamin D₃ in their skin. However, today’s lifestyle often makes vitamin D a nutrient that needs to be obtained through dietary supplementation.

The need to synthesise vitamin D₃ through sunlight exposure has led to a reduction in skin pigmentation—a change that began around 50,000 years ago with the migration of humans from Africa to Asia and Europe².

In other words, the skin of Europeans and all northern populations is lighter because it is exposed to less sunlight and needs to optimise this exposure in order to produce the highest possible amount of vitamin D.

Vitamin K2

Vitamin K2 is very important, primarily because it is associated with the inhibition of arterial calcification and arterial stiffening. Adequate intake of vitamin K2 has been shown to reduce the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits calcium deposits on the endothelial walls³. Unfortunately, vitamin K, particularly in the form of K2, is often present in low amounts even in a varied diet. A deficiency in vitamin K leads to inadequate activation of MGP, which significantly impairs the process of removing calcium from outside the bones and increases the risk of calcification of the blood vessels.

A higher intake of vitamin K2 may be a way to reduce the risks associated with vascular calcification. This is especially useful when taking substantial calcium supplementation⁴.

Vitamin E

Vitamin E is a powerful fat-soluble antioxidant and is found in higher concentrations in immune cells than in other blood cells. It is one of the most effective nutrients for modulating immune functions⁵.

Thanks to its antioxidant properties, it counteracts free radicals and promotes cell renewal.

A deficiency in vitamin E can lead to nervous system disorders and general metabolic issues.

Additionally, it may be beneficial for healthy menopausal women, as it supports an increase in bone density⁶.

Magnesium

Of all the elements, Magnesium is undoubtedly the best known for combating tiredness and low mood. What few people know is that magnesium also helps, together with vitamin K2, to direct calcium to where it is really needed, the bones and teeth, thus avoiding calcification in other tissues⁷.

In the form of citrate (an organic salt), magnesium modulates the body’s pH, preventing acidosis, which can lead the whole body into an inflammatory state. In fact, an acidic environment promotes the dissolution of the bone matrix and the onset of inflammation.

To get the most benefit, we recommend taking two capsules of DKE + Magnesio a day, which give you a total of 2,000 IU of vitamin D3 a day, the maximum allowed for food supplements by the Italian Ministry of Health. In this way, each month you take 60,000 IU of vitamin D3

In particular you can take the two capsules as follows

  • After lunch: one capsule of DKE + Magnesio
  • After dinner: one capsule of DKE + Magnesio

NB: In the case of severe Vitamin D deficiency, or if you have particular bone-strengthening needs, we suggest taking the product in 3-month cycles, 2 or 3 times a year.

Length of the course

You will already be able to see the benefits after the first month. We recommend continuing the course for three months to consolidate and maintain the results obtained over time.

Every time you finish a month of the course, we suggest taking a 2/3-day break before starting the next month. This will make the course even more effective!

At the end of the third month? Call us! We care about you and want to know how you got on. Together with our Experts you will work out how to approach the following period so as not to lose the results obtained!

N.B. Every person is unique. All you have to do is call us or send us an email with any questions or needs. Our experts are at your disposal ;)

Warnings

Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of the reach of children under 3 years of age. Do not exceed the recommended daily dose. The expiry date shown refers to the product when intact and stored in a cool, dry place away from sources of light and heat.

Suggestions

Vitamin K must be administered with caution in patients being treated with vitamin K antagonist anticoagulant medicines, such as dicoumarol derivatives (for example, warfarin and coumadin). As a precaution, we suggest you consult your doctor beforehand if you are taking these medicines.

Ingredients of the Salugea DKE + Magnesio natural supplement

Anhydrous magnesium citrate, Hydroxypropyl methylcellulose capsule, Vitamin E d-α-Tocopheryl acetate from Sunflower (Helianthus annuus L.) seed oil, Vitamin K2 Menaquinone MK-7 from Chickpea (Cicer arietinum L.) flour fermented with Bacillus licheniformis, Vitamin D3 Cholecalciferol from Lichen (Cladonia rangiferina Web.), Silica from Bamboo shoots, Anti-caking agent: Vegetable magnesium stearate.

Ingredients of DKE + Magnesio Salugea

Nutritional Values

AVERAGE AMOUNTS OF NUTRIENTS IN A DAILY DOSE (2 CAPSULES)
Vitamin D3 50 mcg NRV 1000%
Vitamin K2 100 mcg NRV 133%
Vitamin E 60 mg NRV 500%
Magnesium 94 mg NRV 25%

NRV: Nutrient Reference Values

features of DKE + Magnesio

IMPORTANT NOTE ON TAKING VITAMIN D WITH VITAMIN K

Regarding the claim that vitamins D and K cannot be taken together, we would like to clarify the following.

Vitamins D and K have completely different metabolic pathways, so even when taken together they cannot interfere with each other in any way.

There is no validated scientific document confirming this alleged incompatibility.

These claims may have originated from “experimental” – and therefore unapproved – clinical protocols that use huge doses of vitamin D, from 40,000 IU to 320,000 IU a day!

Please remember that the maximum intake set by the Italian Ministry of Health for vitamin D supplementation is 2,000 IU a day. Doses above this limit must be taken ONLY under strict medical supervision, as they are intended for pathological conditions and carry significant side effects.

The functional combination of vitamin D and vitamin K in DKE + Magnesio is therefore entirely legitimate and functional.

Supplementing with vitamin D is important to preserve bone wellbeing and support the immune system.

Vitamin D deficiency and insufficiency are in fact a global health problem affecting more than a billion children and adults worldwide.

The consequences of vitamin D deficiency should not be underestimated. Vitamin D deficiency has been associated with a myriad of acute and chronic diseases, including pre-eclampsia, childhood dental caries, periodontitis, autoimmune diseases, infectious diseases, cardiovascular diseases and more [8].

It is therefore important to make up for this deficiency through supplementation.

Vitamin D in the human body comes mainly from its synthesis in skin cells thanks to sunlight, and to a small extent from the diet.

Today’s lifestyle does not allow us adequate exposure to the sun, especially in the winter months, and a diet that is often poor in nutrients does not guarantee an optimal intake of vitamin D.

Studies have also been carried out to assess the effect of vitamin D supplementation on the risk of acute respiratory tract infection.

Vitamin D supplementation was found to reduce the risk of acute respiratory tract infection among all participants. The greatest benefits were obtained with daily or weekly supplementation, preferably not as a single bolus [9].

For all these reasons, it is important to take vitamin D supplements consistently in order to maintain the physiological functions of the immune system and the wellbeing of bones and teeth.

Finding out whether your vitamin D levels are insufficient is simple. Just ask for them to be checked as part of your routine blood tests.

Vitamin E also supports the immune system.

At the same time, the combination with Vitamin K2 and Magnesium offers protection against calcification of the cardiovascular system and supports bone wellbeing.

VITAMIN D3

  • Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am. 2017 Dec;46(4):1061-1094. doi: 10.1016/j.ecl.2017.07.010. Epub 2017 Oct 6. PMID: 29080635.

There is evidence that vitamin D and its active metabolites play a role in modulating immune function.

In humans, there is evidence of associations between vitamin D deficiency and impaired immune function, leading to autoimmunity in genetically predisposed people and to an increased risk of infection. High-dose vitamin D may improve immune health, prevent autoimmunity and improve defence against infection.

  • Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005 May 11;293(18):2257-64. doi: 10.1001/jama.293.18.2257. PMID: 15886381.

The aim of this meta-analysis was to assess the effectiveness of vitamin D supplementation in preventing hip fractures and non-vertebral fractures in older people.

All the studies used cholecalciferol (vitamin D3).

Oral vitamin D supplementation of between 700 and 800 IU a day appears to reduce the risk of hip fractures and of any non-vertebral fracture in older people. An oral vitamin D dose of 400 IU a day is not sufficient to prevent fractures.

VITAMIN K2

  • Rønn SH, Harsløf T, Pedersen SB, Langdahl BL. Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women. Eur J Endocrinol. 2016 Dec;175(6):541-549. doi: 10.1530/EJE-16-0498. Epub 2016 Sep 13. PMID: 27625301.

Clinical studies suggest that vitamin K2 protects against bone loss and fractures. This study specifically analysed the effect of MK-7 (vitamin K2) on undercarboxylated osteocalcin (ucOC) and on bone mass and quality.

The effect of MK-7 on bone mineral density (BMD) and on bone microarchitecture at the tibia was studied over 12 months.

One group of participants received a placebo, while the other was given calcium and vitamin D supplementation.

The results show that the changes in bone microarchitecture in the placebo group are consistent with age-related deterioration of the trabecular structure, with a loss of trabeculae and an increase in the average thickness of the remaining trabeculae.

In the group taking vitamin K2, however, these structures remained unchanged.

This suggests that vitamin K2 (menaquinone-7) is able to preserve the trabecular bone structure of the tibia.

VITAMIN E

  • Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life. 2019 Apr;71(4):487-494. doi: 10.1002/iub.1976. Epub 2018 Nov 30. PMID: 30501009; PMCID: PMC7011499.

Vitamin E deficiency has been shown to impair the normal functions of the immune system in animals and humans.

Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to improve immune system function and reduce the risk of infection, particularly in older people.

The mechanisms responsible for the effect of vitamin E on the immune system and on inflammation have been explored in in vitro, preclinical and clinical studies.

Vitamin E modulates T-cell function by directly affecting membrane integrity, signal transduction and cell division, and also indirectly by affecting the inflammatory mediators generated by other immune cells.

The modulation of immune function by vitamin E is clinically relevant, as it affects host susceptibility to infectious diseases such as respiratory infections, as well as to allergic diseases such as asthma.

Studies examining the role of vitamin E in the immune system have generally focused on α-tocopherol. However, emerging evidence suggests that other forms of vitamin E, including other tocopherols and tocotrienols, may also have powerful immunomodulatory functions.

MAGNESIUM

  • Yao Z, Xu Y, Ma W, Sun XY, Jia S, Zheng Y, Liu X, Fan Y, Wang C. Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model. J Cardiovasc Pharmacol. 2018 Dec;72(6):270-276. doi: 10.1097/FJC.0000000000000590. PMID: 29738375.

Hypomagnesaemia (low magnesium levels) has been identified as a strong risk factor for cardiovascular disease in patients with chronic renal failure (CRF). The main aim of this study was to determine the effects of magnesium citrate on vascular calcification in rats with chronic renal failure.

The results showed that magnesium citrate plays a protective role against vascular calcification in rats with chronic renal failure. It could therefore be of potential help in preventing vascular calcification.

  • Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin S. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res. 2010 Feb;133(2):136-43. doi: 10.1007/s12011-009-8416-8. Epub 2009 Jun 2. PMID: 19488681.

Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, but its mechanism of action is unclear.

This study investigated the effects of daily oral magnesium supplementation on the biochemical markers of bone turnover.

Twenty postmenopausal women were divided into two groups.

Ten patients were given oral magnesium citrate for 30 days.

Ten postmenopausal women matched for age, duration of menopause and BMI were recruited as a control group and followed up without any medication.

Fasting blood samples and first-void urine samples were collected on days 0, 1, 5, 10, 20 and 30, and parameters such as total magnesium, calcium, phosphorus, parathyroid hormone and osteocalcin were assessed.

This study showed that oral magnesium supplementation in postmenopausal women with osteoporosis slows bone turnover. In this way, bone tissue is protected from breakdown.

Bibliography

[1] Gatti D, Idolazzi L, Fassio A. Vitamin D: not just bone, but also immunity. Minerva Med. 2016 Dec;107(6):452-460. Epub 2016 Jul 21. PMID: 27441391.

[2] Carlberg C. Nutrigenomics of Vitamin D. Nutrients. 2019 Mar 21;11(3):676. doi: 10.3390/nu11030676. PMID: 30901909; PMCID: PMC6470874.

[3] Villa JKD, Diaz MAN, Pizziolo VR, Martino HSD. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences. Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970. doi: 10.1080/10408398.2016.1211616. PMID: 27437760.

[4] Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas). 2015 Feb;14(1):34-9. PMID: 26770129; PMCID: PMC4566462.

[5] Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life. 2019 Apr;71(4):487-494. doi: 10.1002/iub.1976. Epub 2018 Nov 30. PMID: 30501009; PMCID: PMC7011499.

[6] Mata-Granados JM, Cuenca-Acebedo R, Luque de Castro MD, Quesada Gómez JM. Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study. J Bone Miner Metab. 2013 Jul;31(4):455-60. doi: 10.1007/s00774-013-0432-2. Epub 2013 Mar 28. PMID: 23536191.

[7] Yao Z, Xu Y, Ma W, Sun XY, Jia S, Zheng Y, Liu X, Fan Y, Wang C. Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model. J Cardiovasc Pharmacol. 2018 Dec;72(6):270-276. doi: 10.1097/FJC.0000000000000590. PMID: 29738375.

[8] Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017 Jun;18(2):153-165. doi: 10.1007/s11154-017-9424-1. PMID: 28516265.

[9] Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach I, Kumar GT, Urashima M, Camargo CA Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583. PMID: 28202713; PMCID: PMC5310969.

Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

Italian Ministry of Health code:  110645

Food supplement: read the warnings on the label.
Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.

Confronto

Standard Salugea Standard di mercato
Pharmaceutical-grade dark glass bottle ✓ ❌
High content of active ingredients ✓ ❌
Vegetable capsules ✓ ❌
100% natural and pure ✓ ❌

What you won’t find in our formulations

Our idea of 100% natural also includes what we choose not to use.

No GMOs
No Synthetic Additives
No Plastic
No Artificial Sweeteners
No Lactose
No Synthetic Preservatives

Frequently Asked Questions about the Product

For prevention we recommend 1 capsule a day to be taken with meals, and continuing the course especially throughout the winter months. In case of Vitamin D deficiency, we recommend 2 capsules a day to be taken with meals: 1 capsule at lunch and 1 at dinner. Continue this course for 3 months (and repeat it a couple of times a year), with a break of 2 or 3 days between one month and the next.

The daily dose of 2 capsules provides 50 mcg, equivalent to 2,000 IU of Vitamin D.

Salugea DKE + Magnesio can also be taken by people with these intolerances, as it does not contain these substances.

More questions?

If you haven't found the answer to your question, you can contact us:

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800-688-801 (Mon-Fri)

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