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DKE + Magnesio

Vitamin D3, Vitamin K2, Vitamin E and Magnesium

Contenuto: 60 capsules - Spedizione gratuita

"Sono molto soddisfatta di questo integratore perchè i valori degli esami del sangue di vitamina D sono perfetti." - Viviana

€ 42,90

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Notificato al Ministero della Salute Italiano

1 - Who is it for
2 - How to take
3 - Ingredients
4 - Frequently Asked Questions

Vitamin D, K, E and Magnesium Supplement

DKE + Magnesio by Salugea is a 100% natural supplement that combines Vitamin D3, Vitamin K2, Vitamin E, and Magnesium in one single product. This formulation supports the immune system and the strength bones and teeth.

The efficacy of DKE + Magnesio lies in its totally natural formulation including Vitamin D3 derived from lichen, Vitamin K2 extracted from fermented chickpea flour, Vitamin E from sunflower seed oil, and organic Magnesium citrate.

Who is DKE + Magnesio for?

DKE + Magnesio is suitable for those who:

spend a lot of time indoor and do not get enough daylight,
need to support the strength of their bones and teeth in a natural way,
want to boost their immune system,
seek a natural remedy to prevent possible risks of osteopenia and osteoporosis, especially menopausal women,
need to relieve stress and fatigue,
are looking for a powerful anti-age supplement,
need to maintain bone density like the elderly.

What benefits you get from DKE + Magnesio active ingredients

Thanks to DKE + Magnesio active ingredients, you will:

Support long-term bone strength. The combination of vitamins D, K, E, and Magnesium contributes to maintaining bone density and, most importantly, helps prevent calcium loss by directing it to the bones and teeth.
Boost your immune system. Vitamin D has a direct effect on the immune system and therefore helps the body keep pathogens at bay especially during winter.
Sustain bone density during menopause. During this stage - generally from age 45 onward - oestrogen and progesterone levels gradually decline, thus leading to a reduction in bone density. Additionally, the increase in blood lipids typical of menopause - also due to the sexual hormones decline - makes it more difficult for calcium to bind to bone tissue. This is why it is crucial for menopausal women to supplement their diet with natural Vitamin D3 by taking DKE + Magnesium.
Support the cardiovascular system. To prevent the possible risk of cardiovascular calcifications—especially in large vessels—DKE + Magnesio can be paired also with specific blood lipid control treatments to diminish the risk of atherosclerosis.

Why is DKE + Magnesio different from any other Vitamin D supplements?

It comes in pharmaceutical-grade brown glass bottles. Glass is the only material that guarantees long-term product quality and safety, and it is good to the environment!
It is 100% natural.
Its active ingredients are beneficial for both bone structure and the immune system.
It comes in vegetable-based, easy-to-open capsules.
It is suitable for both vegans and vegetarians.
It is gluten-free.

How DKE + Magnesio works

Vitamin D3

Vitamin D is important for both cellular metabolism and immune function, as it regulates calcium homeostasis and modulates the response of both the innate and adaptive immune systems¹.

With sufficient exposure to UV-B rays, humans can endogenously synthesize vitamin D₃ in their skin. However, today’s lifestyle often makes vitamin D a nutrient that needs to be obtained through dietary supplementation.

The need to synthesize vitamin D₃ through sunlight exposure has led to a reduction in skin pigmentation—a change that began around 50,000 years ago with the migration of humans from Africa to Asia and Europe².

In other words, the skin of Europeans and all northern populations is lighter because it is exposed to less sunlight and needs to optimise this exposure in order to produce the highest possible amount of vitamin D.

Vitamin K2

Vitamin K2 is very important, primarily because it is linked to the prevention of arterial calcification and arterial stiffness. Adequate intake of vitamin K2 has been shown to reduce the risk of vascular damage by activating matrix GLA proteins (MGPs), which inhibit calcium deposits on endothelial walls³. Unfortunately, even within a varied diet, vitamin K—particularly in the form of K2—is often present in insufficient amounts. A deficiency in vitamin K leads to inadequate activation of MGPs, which significantly impairs the removal of calcium from outside the bones and increases the risk of vascular calcification.

A higher intake of vitamin K2 may be a way to reduce the risks associated with vascular calcification. This is especially beneficial when taking calcium supplements⁴.

Vitamin E

Vitamin E is a powerful fat-soluble antioxidant and is found in higher concentrations in immune cells than in other blood cells. It is one of the most effective nutrients for modulating immune functions⁵.

Thanks to its antioxidant properties, it neutralizes free radicals and promotes the renewal of cells.

A deficiency in vitamin E can lead to nervous system disorders and general metabolic issues.

Additionally, it may be beneficial for healthy postmenopausal women, as it supports an increase in bone density⁶.

Magnesium

Among all elements, Magnesium is undoubtedly the best-known for its efficacy against fatigue and mood swings. What few people know is that magnesium also plays a role—together with vitamin K2—in directing calcium to where it’s truly needed, such as bones and teeth, thereby preventing unwanted calcification in other tissues⁷.

In the form of citrate (an organic salt), magnesium helps regulate the body’s pH balance, preventing acidosis, a condition that can trigger inflammatory states throughout the body. In fact, an acidic environment promotes the breakdown of bone matrix and the development of inflammation.

DKE + Magnesio - How to Take

For maximum benefits, we recommend that you take two capsules of DKE + Magnesio per day. The daily dosage provides a total of 2,000 IU of Vitamin D3 per day (60.000 I.U. per month) which is the maximum intake allowed by the Italian Ministry of Health for dietary supplements.

Take the two capsules as follows.

After lunch, on a full stomach: 1 capsule of DKE + Magnesio
After dinner, on a full stomach: 1 capsule of DKE + Magnesio

Please Note. In case of severe Vitamin D deficiency or specific bone-strengthening needs, we suggest that you take DKE + Magnesio for at least 3 months and then repeat the 3-month-cycle 2 to 3 times a year.

Duration of treatment

You may start noticing the benefits after just the first month. We recommend continuing the treatment for three months to consolidate and maintain the results over time. At the end of each month, we suggest that you take a 2 to 3 day-break before starting the next one. This will make the treatment even more effective!

What do I do after the third month?

Call us! We care about you and would love to hear how you’re doing. Our Experts will advise you on what to do next in order to maintain the results you’ve achieved.

Please Note. Every person is unique, and the dosage can be adjusted or modified based on individual needs. Feel free to call us or send us an email for any questions you might have. Our Experts are here for you! 😉

Notice

Food supplements are not to be intended as substitutes for a balanced diet and a healthy lifestyle. Keep out of reach of children under three years of age. Do not exceed the recommended daily intake. The best-before date is to be intended for the intact product, stored in a dry and cool place, away from light and heat.

Warnings

Vitamin K should be used with caution in patients undergoing treatment with vitamin K antagonist anticoagulants, such as dicumarol derivatives (e.g. Warfarin and Coumadin). By way of precaution, if you are under treatment with these medications, please seek your physician’s advice before taking DKE + Magnesio.

DKE + Magnesio Natural Supplement Ingredients

Anhydrous Magnesium Citrate, Hydroxypropyl Methylcellulose capsule, Vitamin E (d-α-Tocopheryl Acetate) from Sunflower Seed Oil (Helianthus annuus L.), Vitamin K2 (Menaquinone MK-7) from Chickpea Flour (Cicer arietinum L.) fermented with Bacillus licheniformis, Vitamin D3 (Cholecalciferol) from Lichen (Cladonia rangiferina Web.), Anti-caking agents: Silicon Dioxide, Vegetable Magnesium Stearate.

Nutritional Values

AVERAGE NUTRITIONAL VALUES PER DAILY INTAKE (2 CAPSULES)
Vitamin D3	50 mcg	NRV 1000%
Vitamin K2	100 mcg	NRV 133%
Vitamin E	60 mg	NRV 500%
Magnesium	94 mg	NRV 25%

NRV: Nutritional Reference Values

Scientific Insights

IMPORTANT: WHY SHOULD VITAMIN D AND VITAMIN K BE TAKEN TOGETHER?

Regarding the claim that Vitamins D and K should be taken separately, please find hereafter the reasons why it is recommended, instead, that they be taken together.

Inside our bodies, Vitamins D and K take completely different metabolic pathways, and therefore, when taken together, they do not interfere with each other in any way. There is no validated scientific document that confirms a possible incompatibility.

Such claims may stem from “experimental” clinical protocols, which are not approved, and involve extremely high doses of Vitamin D—ranging from 40,000 IU to 320,000 IU per day!

Bear in mind that, according to Italian the Ministry of Health, the maximum daily intake of Vitamin D for supplements is 2,000 IU per day.

Dosages exceeding this limit should be taken only under strict medical supervision, as they are intended for pathological conditions and might carry significant side effects. Therefore, the combination of Vitamin D and Vitamin K in DKE + Magnesium formulation is completely legitimate and functional.

Supplementing with Vitamin D is important for maintaining bone strength and supporting the immune system.

Vitamin D deficiency and insufficiency are global health issues affecting more than one billion children and adults worldwide.

The consequences of vitamin D deficiency should not be underestimated. Vitamin D deficiency has been associated with a wide range of acute and chronic conditions, including preeclampsia, childhood dental caries, periodontitis, autoimmune diseases, infectious diseases, cardiovascular diseases, and more ^[8].

That’s why it is important to address this deficiency through supplementation.

The presence of vitamin D in the human body is primarily due to its synthesis in skin cells through sun exposure, and only to a small extent to the diet.

However, modern lifestyles limit our sun exposure, especially during the winter months, and nutrient-poor diets often fail to provide adequate amounts of vitamin D.

The effect of vitamin D supplementation has also been studied on the risk of acute respiratory tract infections.

One study, amongst the others, demonstrates that vitamin D supplementation can reduce the risk of acute respiratory infections. The greatest benefits are seen with daily or weekly supplementation, preferably not in large single doses (bolus) [9].

It is, therefore, important to supplement Vitamin D consistently to help maintain the normal function of the immune system and the strength of bones and teeth.

Checking whether your vitamin D levels are low is simple: you just need to request also the Vitamin D test as part of your routine blood test check-ups.

Vitamin E also supports the immune system and the combination with Vitamin K2 and Magnesium offers protection against cardiovascular calcification and supports overall bone strength.

VITAMIN D3

Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am. 2017 Dec;46(4):1061-1094. doi: 10.1016/j.ecl.2017.07.010. Epub 2017 Oct 6. PMID: 29080635.

Evidence exists for a role for vitamin D and its active metabolites in modulating immune functions. In humans, evidence exists on associations between vitamin D deficiency and impaired immune function, leading to autoimmunity in genetically predisposed people and increased risk for infections.

High doses of vitamin D can improve immune health, help prevent autoimmunity, and enhance the body’s defence against infections.

Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005 May 11;293(18):2257-64. doi: 10.1001/jama.293.18.2257. PMID: 15886381.

This meta-analysis aimed to evaluate the effectiveness of vitamin D supplementation in preventing hip fractures and non-vertebral fractures in the elderly. All the studies used cholecalciferol (vitamin D3).

Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in the elderly. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.

VITAMIN K2

Rønn SH, Harsløf T, Pedersen SB, Langdahl BL. Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women. Eur J Endocrinol. 2016 Dec;175(6):541-549. doi: 10.1530/EJE-16-0498. Epub 2016 Sep 13. PMID: 27625301.

Clinical studies suggest that vitamin K2 protects against bone loss and fractures.

This study specifically analysed the effect of MK-7 on undercarboxylated osteocalcin (ucOC) and on bone mass and quality.

The effect of MK-7 on bone mineral density (BMD) and tibial bone microarchitecture was studied over a 12-month period.

One group of participants received a placebo, while the other received calcium and vitamin D supplementation.

The changes in bone microarchitecture in the placebo group are consistent with the age-related deterioration of trabecular structure, with a loss of trabeculae and a greater mean thickness of the remaining trabeculae.

Instead, in the group receiving Vit. D the bone structure remained unchanged.

This suggests that vitamin D (MK-7) preserves the trabecular bone structure of the tibia.

VITAMIN E

Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life. 2019 Apr;71(4):487-494. doi: 10.1002/iub.1976. Epub 2018 Nov 30. PMID: 30501009; PMCID: PMC7011499.

Vitamin E deficiency has been demonstrated to impair normal functions of the immune system in animals and humans.

Although deficiency is rare, vitamin E supplementation above current dietary recommendations has been shown to enhance the function of the immune system and reduce risk of infection, particularly in older individuals. The mechanisms responsible for the effect of vitamin E on the immune system and inflammation have been explored in cell-based, pre-clinical and clinical intervention studies. Vitamin E modulates T cell function through directly impacting T cell membrane integrity, signal transduction, and cell division, and also indirectly by affecting inflammatory mediators generated from other immune cells.

Modulation of immune function by vitamin E has clinical relevance as it affects host susceptibility to infectious diseases such as respiratory infections, in addition to allergic diseases such as asthma.

Studies examining the role of vitamin E in the immune system have typically focused on α-tocopherol. However, emerging evidence suggests that other forms of vitamin E, including other tocopherols as well as tocotrienols, may also have potent immunomodulatory functions.

MAGNESIUM

Yao Z, Xu Y, Ma W, Sun XY, Jia S, Zheng Y, Liu X, Fan Y, Wang C. Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model. J Cardiovasc Pharmacol. 2018 Dec;72(6):270-276. doi: 10.1097/FJC.0000000000000590. PMID: 29738375.

Hypomagnesemia (low magnesium levels) was identified as a strong risk factor for cardiovascular disease in patients with chronic renal failure (CRF).

The main objective of this study was to determine the effects of magnesium citrate on vascular calcification in rats with chronic kidney disease.

The results showed that magnesium citrate plays a protective role against vascular calcification in rats with chronic kidney disease.

Therefore, it may be a potential aid in the prevention of vascular calcification.

Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin S. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res. 2010 Feb;133(2):136-43. doi: 10.1007/s12011-009-8416-8. Epub 2009 Jun 2. PMID: 19488681.

Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, yet its mechanism of action is obscure.

In this study, the effects of daily oral magnesium supplementation on biochemical markers of bone turnover were investigated.

Twenty postmenopausal women have been divided into two groups.

Ten patients were given magnesium citrate orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as the control group and followed without any medication.

Fasting blood and first-void urine samples were collected on days 0, 1, 5, 10, 20, and 30, respectively. Total magnesium, calcium, phosphorus, iPTH and osteocalcin were determined in blood samples.

This study has demonstrated that oral magnesium supplementation in postmenopausal osteoporotic women suppresses bone turnover thus allowing for the bone tissue to be preserved.

Bibliography

^[1] Gatti D, Idolazzi L, Fassio A. Vitamin D: not just bone, but also immunity. Minerva Med. 2016 Dec;107(6):452-460. Epub 2016 Jul 21. PMID: 27441391.

^[2] Carlberg C. Nutrigenomics of Vitamin D. Nutrients. 2019 Mar 21;11(3):676. doi: 10.3390/nu11030676. PMID: 30901909; PMCID: PMC6470874.

^[3] Villa JKD, Diaz MAN, Pizziolo VR, Martino HSD. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences. Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970. doi: 10.1080/10408398.2016.1211616. PMID: 27437760.

^[4] Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas). 2015 Feb;14(1):34-9. PMID: 26770129; PMCID: PMC4566462.

^[5] Lewis ED, Meydani SN, Wu D. Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life. 2019 Apr;71(4):487-494. doi: 10.1002/iub.1976. Epub 2018 Nov 30. PMID: 30501009; PMCID: PMC7011499.

^[6] Mata-Granados JM, Cuenca-Acebedo R, Luque de Castro MD, Quesada Gómez JM. Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study. J Bone Miner Metab. 2013 Jul;31(4):455-60. doi: 10.1007/s00774-013-0432-2. Epub 2013 Mar 28. PMID: 23536191.

^[7] Yao Z, Xu Y, Ma W, Sun XY, Jia S, Zheng Y, Liu X, Fan Y, Wang C. Magnesium Citrate Protects Against Vascular Calcification in an Adenine-induced Chronic Renal Failure Rat Model. J Cardiovasc Pharmacol. 2018 Dec;72(6):270-276. doi: 10.1097/FJC.0000000000000590. PMID: 29738375.

^[8] Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017 Jun;18(2):153-165. doi: 10.1007/s11154-017-9424-1. PMID: 28516265.

^[9] Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach I, Kumar GT, Urashima M, Camargo CA Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583. PMID: 28202713; PMCID: PMC5310969.

Disclaimer

The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition.

I nostri testi hanno scopo divulgativo, non vanno intesi come indicazione di diagnosi e cura di stati patologici e non vogliono sostituirsi in alcun modo al parere del Medico.

Cod. Min. Sal.: 110645

DKE + Magnesio

Description

Vitamin D, K, E and Magnesium Supplement

Who is DKE + Magnesio for?

What benefits you get from DKE + Magnesio active ingredients

Why is DKE + Magnesio different from any other Vitamin D supplements?

How DKE + Magnesio works

Vitamin D3

Vitamin K2

Vitamin E

Magnesium

DKE + Magnesio - How to Take

Duration of treatment

DKE + Magnesio Natural Supplement Ingredients

Nutritional Values

Scientific Insights

IMPORTANT: WHY SHOULD VITAMIN D AND VITAMIN K BE TAKEN TOGETHER?

Bibliography

DKE + Magnesio

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