If you are in perimenopause

If you are in perimenopause (no periods for at least 3 or 4 months, or if you skip a period every now and then), take 1 capsule a day, at least one hour away from meals (mid-morning or mid-afternoon, or in the evening when you go to bed if the discomfort is present mainly at night).

If the discomfort is very marked and does not pass after 10-12 days of use, move up to 2 capsules a day:

• mid-morning, at least one hour away from meals: 1 capsule of Pausanorm Forte
• mid-afternoon, at least one hour away from meals: 1 capsule of Pausanorm Forte.

If and when your period comes, suspend use and resume it once it has ended.

Continue taking it for at least three months or until the discomfort has ceased. From then on, you can try moving to just 1 capsule a day as maintenance.

If, during the maintenance phase, the discomfort tends to return, it means that for you the optimal daily dose is 2 capsules.

If you are in menopause

If you are in menopause (no periods for at least 12 months), take two capsules a day as follows:

• mid-morning, at least one hour away from meals: 1 capsule of Pausanorm Forte
• mid-afternoon, at least one hour away from meals: 1 capsule of Pausanorm Forte.

If the discomfort is present mainly at night, you can also take the second capsule in the evening, when you go to bed.

Continue taking it for at least three months or until the discomfort has ceased. From then on, you can try moving to just 1 capsule a day as maintenance.

If, during the maintenance phase, the discomfort tends to return, it means that for you the optimal daily dose is 2 capsules.

If your periods should return (this can happen even in menopause, and it is a sign of the action of the ingredients), suspend use and resume it once they have finished.

Since, among its other ingredients, Pausanorm Forte contains phyto-oestrogens and phyto-progestogens, you will be acting on the hormonal balance that is usually lost with the menopause. For this reason, once the discomfort has ceased, it is a good idea to continue taking it.

If you stop taking it, menopausal discomfort tends to return.

Important

• If you are undergoing drug treatment, always ask your doctor for their opinion too, as an extra precaution.
• In the case of thyroid problems and any intake of thyroid hormones there is no interference, but the beneficial effects of the product will take a little longer than usual to make themselves felt. Do not take the medicine and the supplement at the same time, but preferably at least one hour apart from each other.
• The use of the Pausanorm Forte supplement is NOT indicated if hormone replacement therapy (HRT) in any form is under way, if you are being given female sex hormones in any form (e.g. the pill or a hormone-releasing coil, vaginal gel) or if you have a personal history of neoplasms sensitive to sex hormones.

If you like, give us a call during the course! We are interested in you and want to know how you feel. Every person is one of a kind. For any questions or needs, just call us or send us an email. Our experts are at your disposal ;)

On its own, the formula of Pausanorm Forte already gives excellent results. If you want to make its action even more complete, you can combine it with those of:

• Omega 3 Krill Oil to provide essential fatty acids (EPA and DHA) that are fundamental for the wellbeing of the heart and circulation;
• Rilassa Mente based on plant extracts useful for supporting mood, such as Griffonia and Jujube, and avoiding stress and emotional tension;
• DKE + Magnesio for the supply of Vitamin D3, K2, E and Magnesium; it provides 2,000 IU of vitamin D a day, the maximum intake approved by the Italian Ministry of Health for food supplements, for the wellbeing of the bones;
• Sanuril Enhanced Formula, with Cranberry, Uva Ursi and other ingredients for all-round urinary tract wellbeing;
• Sanaos New Formula with ingredients useful for the wellbeing of joints, tendons and ligaments (including Devil's Claw and Boswellia);
• Cartilagea with ingredients such as vitamin C, Manganese and Copper useful for the wellbeing of joint cartilage, plus hydrolysed Collagen, Chondroitin and Glucosamine;
• LuxGea Pelle for the beauty of the skin of the face and body, based on Silicon, Zinc and Selenium, plus hyaluronic acid, hydrolysed collagen, elastin and vitamins;
• ProbioGea Donna to provide specific probiotics for the wellbeing of the female urogenital system (L. plantarum, L. rhamnosus, B. animalis subsp. lactis[18]).

WARNINGS

Supplements are not to be understood as substitutes for a varied and balanced diet. Keep out of the reach of children under 3 years of age. Do not exceed the recommended dose. The expiry date shown refers to the intact product, stored in a cool, dry place. Do not use during pregnancy or breastfeeding.

Ingredients

Wild Yam (Dioscorea villosa L.) rhizome dry extract, titr. to 20% diosgenin; Dong Quai (Angelica sinensis Diels.) root dry extract, titr. to 1% ferulic acid; Kudzu (Pueraria montana var. lobata (Willd.) S. & P.) root dry extract, titr. to 40% isoflavones; Capsule in hydroxypropylmethylcellulose; Vervain (Verbena officinalis L.) leaves and flowers dry extract, titr. to 5% saponins; Red Clover (Trifolium pratense L.) flowers dry extract, titr. to 8% isoflavones; Anti-caking agents: vegetable magnesium stearate; bamboo shoot-derived silica. The extracts are on a maltodextrin carrier.

PAUSANORM Forte - Nutritional Values

The menopause is a natural stage in a woman’s life, during which significant changes occur on both a physical and an emotional level[19].

Starting from premenopause, the production of the hormones that regulate the reproductive system in fertile women – oestrogens and progesterone – steadily declines.

As a result, the menstrual cycle becomes irregular (periods may be absent for a few months or come closer together) until it stops altogether.

The gradual decline in oestrogens that occurs in this phase is the main cause of the typical, bothersome complaints of the menopause[20].

To make up for this progressive decline, people usually turn to food supplements based on isoflavones, a family of natural molecules that can “mimic” the activity of oestrogens.

From Soya to Red Clover and Kudzu: more effective and more easily absorbed

First-generation menopause supplements offered isoflavones from Soya (Glycine max). However, they are not very effective in counteracting menopause-related complaints[21].

Today, modern menopause supplements NO LONGER include soya because it contains only 2 isoflavones (Genistein and Daidzein), in a glycosylated form that prevents their optimal and rapid absorption in the human body[22], and as a result they are of very limited effectiveness.

In addition, the soya available on the market today is more and more often genetically modified.

In the natural and herbal products sector, increasing attention is being paid to avoiding plant extracts from GMO crops⁴.

For these reasons, second-generation menopause supplements have moved on to other plant active ingredients, in particular Red Clover (Trifolium pratense), which provides as many as 4 isoflavones, most of which are already in an absorbable form, without the glycoside part, making them more rapidly absorbed and more bioavailable[23].

Red Clover is therefore better suited than soya to supporting menopausal women, and at Salugea we have combined it with Kudzu (Pueraria lobata), a wild plant native to Japan.

As well as providing as many as 6 different types of isoflavones, Kudzu is particularly effective in rebalancing the cardiovascular imbalances of the menopause, such as blood pressure swings, hypertension and palpitations¹¹.

The effectiveness of Kudzu extract is also due to one of its particular isoflavones, Puerarin¹¹, which, as well as being easily absorbed, stands out for its very high bioavailability, remarkable stability and longer persistence in the bloodstream compared with other types of isoflavones.

The Dioscorea innovation

Over time, isoflavones extracted from Red Clover and Kudzu have therefore replaced those extracted from soya. Their oestrogen-like function helps make up for the sudden lack of oestrogens in menopausal women.

But, as mentioned, levels of progesterone, another important hormone, also fall during this phase. How can it be supplemented?

By adding Dioscorea plant extract, which provides a specific active ingredient (Diosgenin) with a natural “progestogenic” action and is therefore useful for true hormonal balance¹³.

Let’s now look at some in-depth studies carried out on these active ingredients.

Experimental Phytotherapy

The Pausanorm Forte formulation contains Red Clover, Kudzu, Dioscorea, Angelica Sinensis and Vervain.

Red Clover

• J Obstet Gynaecol. 2016;36(3):301-11. doi: 10.3109/01443615.2015.1049249. Epub 2015 Oct 15. Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. Ghazanfarpour M, Sadeghi R, Roudsari RL, Khorsand I, Khadivzadeh T, Muoio B

This study assessed the effectiveness of red clover in relieving hot flushes and menopausal symptoms in peri/postmenopausal women. The average frequency of hot flushes in the red clover groups was lower than in the control groups. In addition, subjective (vaginal dryness) and objective symptoms of vaginal atrophy showed a significant improvement with a dose of 80 mg of red clover a day.

Kudzu

• Puerarin: a review of pharmacological effects. Zhou YX, Zhang H, Peng C. Phytother Res. 2014 Jul;28(7):961-75. doi: 10.1002/ptr.5083. Epub 2013 Dec 13. Review.

This study analysed the beneficial effects of puerarin in various physiological applications. These may all be due to its broad spectrum of functional properties, such as vasodilation, cardioprotection, neuroprotection, antioxidant, anti-inflammatory and analgesic action, support for bone formation, inhibition of alcohol absorption and attenuation of insulin resistance.

• Br J Nutr . 2003 Jun;89 Suppl 1:S45-58. doi: 10.1079/BJN2002796. Bioavailability of phyto-oestrogens. Ian Rowland 1, Marian Faughnan, Leane Hoey, Kristiina Wähälä, Gary Williamson, Aedin Cassidy

This study focused on how differently isoflavones are absorbed depending on the type chosen. Kudzu is among the most easily absorbed. This sets it apart from soya, whose bioavailability is less certain.

Dioscorea Villosa

• Am J Chin Med. 2009;37(1):159-67.doi: 10.1142/S0192415X09006746. Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf-7 human breast cancer cells. Mi-Kyung Par, Hyeok-Yi Kwon, Woong-Shick Ahn, Sumi Bae, Mee-Ra Rhyu, Youngjoo Lee

According to this study, Dioscorea works by increasing the activity of progesterone receptors in cells sensitive to this hormone, managing to stimulate a physiological response even when the hormone is present in small amounts. This makes it useful during the menopause to help restore hormonal balance.

Angelica Sinensis

• Estrogenic activity of standardized extract of Angelica sinensis. Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F. Phytother Res. 2006 Aug;20(8):665-9.

This study assessed and demonstrated the oestrogenic activity of a standardised extract of Angelica sinensis roots, used to relieve climacteric symptoms.

Vervain

• Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn. Lai SW, Yu MS, Yuen WH, Chang RC. Neuropharmacology. 2006 May;50(6):641-50. Epub 2006 Jan 6.

In this study, researchers demonstrated the neuroprotective effects of Verbena officinalis and showed that these are not merely the product of “folk medicine” beliefs, but can be verified using scientific methods.

Bibliography

[1] Kim JE, Jeong H, Hur S, Lee J, Kwon O. Efficacy and Safety of Kudzu Flower-Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial. Nutrients. 2020;12(11):3237. Published 2020 Oct 22. doi:10.3390/nu12113237.

[2] Grandi G, Facchinetti F, Melotti C, Sgandurra A. Phyto-progestins for the treatment of abnormal uterine bleeding without organic cause in women at high risk for breast cancer and breast cancer survivors: a prospective, pilot study. Gynecol Endocrinol. 2023;39(1):2239936. doi:10.1080/09513590.2023.2239936.

[3] Vitale DC, Piazza C, Melilli B, Drago F, Salomone S. Isoflavones: estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet. 2013;38(1):15-25. doi:10.1007/s13318-012-0112-y.

[4] Editoriale Domani – Politica – Mondo – L’Esperienza del Brasile – La soia è ovunque, anche dove non immagini. Ed è tutta ogm. [Brazil’s experience – Soya is everywhere, even where you wouldn’t imagine. And it’s all GMO.]

[5] Hadi THS, Santoso B, Hardianto G, Kurniawati EM. The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis. Obstet Gynecol Sci. 2025;68(2):131-138. doi:10.5468/ogs.24282.

[6] Lipovac M, Chedraui P, Gruenhut C, Gocan A, Kurz C, Neuber B, Imhof M. Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. Obstet Gynecol Int. 2011;2011:949302. doi: 10.1155/2011/949302. Epub 2011 Nov 1. PMID: 22135679; PMCID: PMC3206499.

[7] Wang S, Zhang S, Wang S, Gao P, Dai L. A comprehensive review on Pueraria: Insights on its chemistry and medicinal value. Biomed Pharmacother. 2020;131:110734. doi:10.1016/j.biopha.2020.110734.

[8] J Obstet Gynaecol. 2016;36(3):301-11. doi: 10.3109/01443615.2015.1049249. Epub 2015 Oct 15. Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. Ghazanfarpour M, Sadeghi R, Roudsari RL, Khorsand I, Khadivzadeh T, Muoio B..

[9] Goyal N, Chaudhary R, Aggarwal K, et al. Red Clover Supplementation Alleviates Neurological Deficits in Estrogen Deficient Rats Exposed to Chronic Unpredictable Mild Stress. Eur J Neurosci. 2025;61(12):e70164. doi:10.1111/ejn.70164.

[10] Zhou YX, Zhang H, Peng C. Puerarin: a review of pharmacological effects. Phytother Res. 2014 Jul;28(7):961-75. doi: 10.1002/ptr.5083. Epub 2013 Dec 13. PMID: 24339367.

[11] Kim JE, Jeong H, Hur S, Lee J, Kwon O. Efficacy and Safety of Kudzu Flower-Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial. Nutrients. 2020;12(11):3237. Published 2020 Oct 22. doi:10.3390/nu12113237.

[12] Semwal P, Painuli S, Abu-Izneid T, et al. Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives. Oxid Med Cell Longev. 2022;2022:1035441. Published 2022 May 29. doi:10.1155/2022/1035441.

[13] Climacteric. 2011 Feb;14(1):132-9. doi: 10.3109/13697137.2010.498594. Epub 2010 Jul 23. The assessment of efficacy of Dioscorea alata for menopausal symptom. Hsu CC, Kuo HC, Chang SY, Wu TC, Huang KE.

[14] Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res. 2006;20(8):665-669. doi:10.1002/ptr.1928.

[15] Xin YF, Zhou GL, Shen M, et al. Angelica sinensis: a novel adjunct to prevent doxorubicin-induced chronic cardiotoxicity. Basic Clin Pharmacol Toxicol. 2007;101(6):421-426. doi:10.1111/j.1742-7843.2007.00144.x.

[16] Chen SW, Min L, Li WJ, Kong WX, Li JF, Zhang YJ. The effects of angelica essential oil in three murine tests of anxiety. Pharmacol Biochem Behav. 2004;79(2):377-382. doi:10.1016/j.pbb.2004.08.017.

[17] Makino, Y., Kondo, S., Nishimura, Y. et al. Hastatoside and verbenalin are sleep-promoting components in Verbena officinalis. Sleep Biol. Rhythms 7, 211–217 (2009). https://doi.org/10.1111/j.1479-8425.2009.00405.x.

[18] Vicariotto F, Malfa P, Viciani E, et al. Efficacy of Lactiplantibacillus plantarum PBS067, Bifidobacterium animalis subsp. lactis BL050, and Lacticaseibacillus rhamnosus LRH020 in the Amelioration of Vaginal Microbiota in Post-Menopausal Women: A Prospective Observational Clinical Trial. Nutrients. 2024 Jan 30;16(3):402. doi: 10.3390/nu16030402. PMID: 38337685; PMCID: PMC10857347.

[19] Nature Menopause. S.R. Davis, I.Lambrinoudaki, M. Lumsden, G.D. Mishra, L. Pal, M. Rees, N. Santoro & T. Simoncini.

[20] Ministero della Salute - Salute della Donna – Menopausa [Italian Ministry of Health – Women’s Health – Menopause].

[21] Levis S, Strickman-Stein N, Ganjei-Azar P, Xu P, Doerge DR, Krischer J. Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms: A Randomized, Double-blind Trial. Arch Intern Med. 2011;171(15):1363–1369. doi:10.1001/archinternmed.2011.330.

[22] Br J Nutr. 2003 Jun;89 Suppl 1:S45-58. Bioavailability of phyto-oestrogens. Rowland I, Faughnan M, Hoey L, Wähälä K, Williamson G, Cassidy A..

[23] Maul R, Kulling SE. Absorption of red clover isoflavones in human subjects: results from a pilot study. Br J Nutr. 2010 Jun;103(11):1569-72. doi: 10.1017/S0007114509993564. Epub 2010 Jan 13. PMID: 20067656.

Pausanorm Forte is a food supplement: read the warnings on the label. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Our content is for informational purposes only: it is not intended as an indication for the diagnosis or treatment of medical conditions and is in no way meant to replace your doctor’s advice.

Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

Italian Ministry of Health code:  68961