To get the most out of its benefits, we recommend taking two capsules of Liposan Forte New Formula a day, straight after dinner.

Length of the course with Liposan Forte New Formula, the food supplement for cholesterol and triglycerides

You will notice the benefits after just a few weeks. We recommend continuing the course for three months to consolidate the results achieved and maintain them over time.

Each time you finish a month of treatment, we suggest taking a 2/3-day break before starting the following month. This break is not compulsory, but it helps make the treatment even more effective over time!

At the end of the third month, we recommend repeating your blood tests and checking the values you have reached. If your cholesterol is back within range, you can move on to the maintenance phase.

Maintenance phase

Take one capsule a day, preferably after dinner, keeping the 2/3-day breaks between one month and the next.

If you like, give us a call at the end of the course! We care about you and want to know how you got on.

Together with our experts you will work out how to approach the following period to maintain the results achieved!

N.B. Every person is one of a kind and can adjust or change the dosages according to their own needs. Just call us or send us an email for any questions or needs. Our experts are at your disposal ;)

If you are taking cholesterol medication

If you are already taking Cholesterol medication, you cannot take Liposan Forte New Formula as well.

Recommended synergies

On its own, Liposan Forte New Formula already gives you excellent results. If you want to make its action even more complete, you can combine it with:

• Omega 3 Krill Oil. It provides EPA and DHA, essential fatty acids that help contribute to the normal function of the heart and circulation. Omega 3s from Krill are up to four times more assimilable than those from fish oil⁴!
• Salugea Organic Acai Juice. Made exclusively from organic Acai berries. Acai berries have a significant antioxidant action and help the metabolism of lipids and carbohydrates. In this way they protect and support the cardiovascular system and are also useful for keeping blood fats and cholesterol under control.
• Epasal. Based on active ingredients (Milk Thistle, Phyllanthus, Olive leaves, Artichoke and Fumitory) that cleanse the liver and, more generally, the body. Olivattiva® is Epasal's ace up the sleeve. It is a patented extract from olive leaves that manages to concentrate Oleuropein to the exclusive level of 70%! Liver cleansing is essential in any cholesterol control journey.

Warnings

Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of reach of children under 3 years of age. Do not exceed the maximum daily dose (2 caps). The expiry date refers to the product when intact and stored in a cool, dry place. Do not consume a daily amount of 3 mg or more of monacolins from red yeast rice. Do not consume during pregnancy or breastfeeding, or if you are under 18 or over 70 years of age. Ask your doctor for advice on the consumption of this product if any health problems occur. Do not consume if you are taking cholesterol medication or if you are already consuming other products containing fermented red rice.

Barberry (Berberis aristata DC.) bark d.e. titr. to 97% berberine; Hydroxypropylmethylcellulose capsule; Milk Thistle (Silybum marianum Gaertn.) fruit d.e. titr. to 80% silymarin; Garlic (Allium sativum L.) bulb d.e. titr. to 0.3% S-allylcysteine; Red Fermented Rice (Monascus purpureus on Oryza sativa L.) d.e. titr. to 5% total monacolins; Rosemary (Rosmarinus officinalis L.) leaf d.e. titr. to 50% ursolic acid; Silica from Bamboo sprouts; Anti-caking agent: Vegetable magnesium stearate. Dry extracts are supported on maltodextrins.

Excess cholesterol and triglycerides are silent conditions that do not show themselves through particular symptoms and are very widespread in Italy⁵.

We often fail to notice them because we pay attention to other, more evident situations such as high blood pressure, recurring vascular problems, excess weight, etc.

At other times (and more frequently than we might imagine) excess cholesterol and triglycerides can be of genetic origin⁶.

There are, in fact, some people who have high levels of cholesterol and/or triglycerides in their blood regardless of diet and lifestyle (smoking, alcohol, sedentary habits).

This happens because cholesterol levels do not depend only on how we eat. As well as exogenous cholesterol (taken in with food), there is also endogenous cholesterol, the kind produced by our own body.

Endogenous or exogenous cholesterol aside, what is really relevant is that these are extremely widespread situations.

Just think that hypercholesterolaemia, or high cholesterol, affects around 54% of the European population, equally among men and women, the latter especially after the age of 50 ⁷.

And it represents the most widespread cardiovascular risk factor in Italy. One last figure, but not least in importance: 40% of those suffering from hypercholesterolaemia are not even aware of it! ⁸

Just by reading these figures, we immediately understand what a fundamental role prevention plays.

What does prevention mean in practice?

• Regular check-ups with medical examinations, specific tests and analyses.
• Taking care of the quality and quantity of your diet.
• Not smoking and not drinking alcohol.
• Taking regular physical exercise.
• Taking appropriate supplementation.

Experimental Phytotherapy

Liposan Forte New Formula is a 100% natural supplement, based on Red Yeast Rice (Total Monacolins (including K) 3 mg/day) and standardised dry extracts of Barberry, Milk Thistle, Aged Garlic and Rosemary.

In particular, the combination of Monacolin, Silymarin, Berberine and Rosemary proved effective in reducing total cholesterol, LDL cholesterol and triglycerides (approx. - 20% in 3 months) in a functional clinical study (Piante medicinali vol. 15(4) 2016 ed. Si.Fit. - Capriotti F., Censani S.)

Red Yeast Rice:

• Cicero AFG, Fogacci F, Banach M. Red Yeast Rice for Hypercholesterolemia. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):192-199. doi: 10.14797/mdcj-15-3-192. PMID: 31687098; PMCID: PMC6822657.

This retrospective work found that Red Yeast Rice is currently the most effective natural remedy for containing blood cholesterol levels. In particular for the parameters of Total cholesterol, LDL Cholesterol and Apolipoprotein B, determining factors for cardiovascular wellbeing. This against a minimal possibility of the onset of undesirable effects, limited to the subjects most sensitive to monacolin K, who may experience mild myalgia, in any case reversible on discontinuing the active ingredient.

• Heinz T, et al. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016 Oct;36(10):1162-1170. doi: 10.1016/j.nutres.2016.07.005. Epub 2016 Jul 27. PMID: 27865358.

This interesting German study shows that even a dosage of 3 mg/day of Monacolin K is able to reduce by almost 15% the level of LDL cholesterol, the most harmful form of cholesterol for the protection of the cardio-circulatory system. Therefore this dosage, too, is useful for normalising the degree of cardiovascular risk.

Barberry:

• Kong W, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004 Dec;10(12):1344-51. doi: 10.1038/nm1135. Epub 2004 Nov 7. PMID: 15531889.

This functional study on humans showed that the administration of Berberine, the active ingredient of Barberry, over the course of 3 months was able to reduce Total Cholesterol levels by 29%, Triglycerides by 35% and LDL Cholesterol by 25%. These results confirm that Berberine is a powerful natural active ingredient useful for normalising lipaemic values, so important for cardiovascular wellbeing, with a mechanism different from and complementary to that of statins.

• Ju J, Li J, Lin Q, Xu H. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials. 2018 Nov 15;50:25-34. doi: 10.1016/j.phymed.2018.09.212. Epub 2018 Sep 28. PMID: 30466986.

This work summarised the data obtained from no fewer than 16 different functional studies on Berberine from Barberry, with a total population of 2'147 patients. The findings confirm that the use of Barberry is able to reduce the levels of Total Cholesterol, LDL Cholesterol and Triglycerides, while favouring an increase in HDL Cholesterol, the “good” fraction, the one that is useful and favours cardio-circulatory wellbeing.

Milk thistle

• Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F. Silymarin in non alcoholic fatty liver disease. World J Hepatol. 2013 Mar 27;5(3):109-13. doi: 10.4254/wjh.v5.i3.109. PMID: 23556042; PMCID: PMC3612568.

This study confirms the great hepatoprotective properties of Milk thistle and its active ingredient Silymarin on liver function. The effect of a Milk thistle extract standardised in Silymarin was tested on 72 patients suffering from non-alcoholic fatty liver: after 3 months the main parameters monitored had improved, including the blood values for atherosclerosis, determining factors for the reduction of cardiovascular risk.

• Formisano E, et al. Efficacy of Nutraceutical Combination of Monacolin K, Berberine, and Silymarin on Lipid Profile and PCSK9 Plasma Level in a Cohort of Hypercholesterolemic Patients. J Med Food. 2020 Jun;23(6):658-666. doi: 10.1089/jmf.2019.0168. Epub 2019 Oct 30. PMID: 31663806.

The study reported here found, in 53 patients with congenital hypercholesterolaemia, that a combination of Monacolin, Berberine and Silymarin offers results similar to those obtained with Atorvastatin, a synthetic statin, especially with regard to LDL Cholesterol. Improvements were also observed in the p-CSK-9 protein, a critical element in congenital cholesterol dyslipidaemias, something not achievable with the use of Atorvastatin. All this leads to the conclusion that this combination of natural active ingredients can play an important regularising role on the levels of fats in the blood.

Aged garlic

• Jung ES, et al. Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial. 2014 Sep;30(9):1034-9. doi: 10.1016/j.nut.2014.02.014. Epub 2014 Mar 12. PMID: 24976429.

The action of Aged Garlic (also known as Black Garlic) was tested on 60 participants in this double-blind placebo-controlled study. After 12 weeks it was found that the members of the test group showed improved parameters compared with the placebo group as regards HDL Cholesterol and Apolipoprotein B values, determining factors for a more favourable degree of cardiovascular wellbeing. This highlighted the protective effect that Aged Garlic can exert on the circulatory system.

• Munday JS, et al. Daily supplementation with aged garlic extract, but not raw garlic, protects low density lipoprotein against in vitro oxidation. 1999 Apr;143(2):399-404. doi: 10.1016/s0021-9150(98)00293-7. PMID: 10217370.

LDL isolated from subjects given an Aged Garlic extract, but not raw garlic, was significantly more resistant to oxidation than LDL isolated from subjects receiving no supplements. These results suggest that the antioxidant and anti-atherogenic effects of Aged Garlic may be useful in preventing atherosclerotic disease, thus reducing the degree of cardiovascular risk.

Rosemary

• Kim GH, et al. Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells. Int J Mol Sci. 2019 Sep 26;20(19):4767. doi: 10.3390/ijms20194767. PMID: 31561416; PMCID: PMC6802365.

This interesting in vitro study found that Ursolic acid, a natural pentacyclic terpenoid present in Rosemary, is able to counter the endogenous production of cholesterol by cultured liver cells. The data that emerged may therefore lead to the conclusion that Ursolic acid could be a promising cholesterol-lowering nutraceutical for the prevention and treatment of patients with chronic diseases linked to excess cholesterol.

• Tu Z, Moss-Pierce T, Ford P, Jiang TA. Rosemary (Rosmarinus officinalis L.) extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells. J Agric Food Chem. 2013 Mar 20;61(11):2803-10. doi: 10.1021/jf400298c. Epub 2013 Mar 6. PMID: 23432097.

This work starts from the observation that rosemary has been experimentally shown to lower blood glucose and cholesterol levels in several in vivo studies. On a liver cell culture it was found that a rosemary extract is potentially able to increase hepatic glycolysis and fatty acid oxidation. These effects underlie the body's metabolic wellbeing and are important for preventing and keeping under control the levels of sugars and fats in the blood, basic parameters for the general wellbeing of the body.

N.B. Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

References:

¹ Lin CC, Li TC, Lai MM. Efficacy and safety of Monascus purpureus Went rice in subjects with hyperlipidemia. Eur J Endocrinol. 2005 Nov;153(5):679-86. doi: 10.1530/eje.1.02012. PMID: 16260426.⁴ https://pubmed.ncbi.nlm.nih.gov/20858178/

² Federico A, Dallio M, Loguercio C. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules. 2017 Jan 24;22(2):191. doi: 10.3390/molecules22020191. PMID: 28125040; PMCID: PMC6155865.

³ Iloon Kashkooli R, et al. The effect of berberis vulgaris extract on transaminase activities in non-alcoholic Fatty liver disease. Hepat Mon. 2015 Feb 5;15(2):e25067. doi: 10.5812/hepatmon.25067. PMID: 25788958; PMCID: PMC4350248.

⁴ Ulven SM, et al. Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids. 2011 Jan;46(1):37-46. doi: 10.1007/s11745-010-3490-4. Epub 2010 Nov 2. PMID: 21042875; PMCID: PMC3024511.

⁵ Epicentro – Istituto Superiore di Sanità - Epidemiological aspects: Hypercholesterolaemia in Italy.

⁶ ANIF - Associazione Nazionale Ipercolesterolemia Familiare - Answers to questions on hypercholesterolaemia.

⁷ Quotidianosanita.it - Daiichi Sankyo Italia, a campaign to prevent hypercholesterolaemia.

⁸ Istituto Superiore di Sanità: Progetto Cuore 2012.

Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

Italian Ministry of Health code: 147597