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Flacone di Autofagia Salugea Longevity con Spermidina, NADH e Polidatina, 60 capsule vegetali
Autofagia capsule held between the fingers
Ingredienti di Autofagia: Spermidina, NADH, Polidatina, Griffonia, Vitamina C da Rosa Canina, Zinco e Selenio
Benefici di Autofagia: processo fisiologico di autofagia, funzionalità mitocondriale, metabolismo energetico e longevity
Caratteristiche di Autofagia: senza lattosio, no OGM, capsule vegetali, flacone in vetro scuro, ingredienti 100% naturali
Come usare il sigillo di sicurezza sotto il tappo del flacone di Autofagia in quattro passaggi
Perché Salugea: Autofagia a confronto con gli integratori classici per principi attivi, flacone in vetro e capsule
Coppia sorridente in camicia di jeans, Autofagia con Spermidina, Polidatina e NADH per i fisiologici processi autofagici
Etichetta di Autofagia Longevity con ingredienti, apporti per 2 capsule, modalità d'uso e avvertenze
numero 3 confezioni di Autofagia Salugea
numero 6 confezioni di Autofagia Salugea
Flacone di Autofagia Salugea Longevity con Spermidina, NADH e Polidatina, 60 capsule vegetaliAutofagia capsule held between the fingersIngredienti di Autofagia: Spermidina, NADH, Polidatina, Griffonia, Vitamina C da Rosa Canina, Zinco e SelenioBenefici di Autofagia: processo fisiologico di autofagia, funzionalità mitocondriale, metabolismo energetico e longevityCaratteristiche di Autofagia: senza lattosio, no OGM, capsule vegetali, flacone in vetro scuro, ingredienti 100% naturaliCome usare il sigillo di sicurezza sotto il tappo del flacone di Autofagia in quattro passaggiPerché Salugea: Autofagia a confronto con gli integratori classici per principi attivi, flacone in vetro e capsuleCoppia sorridente in camicia di jeans, Autofagia con Spermidina, Polidatina e NADH per i fisiologici processi autofagiciEtichetta di Autofagia Longevity con ingredienti, apporti per 2 capsule, modalità d'uso e avvertenzenumero 3 confezioni di Autofagia Salugeanumero 6 confezioni di Autofagia Salugea
Cellular renewal

Autofagia

Contenuto: 60 vegetable capsules

Trustpilot

With Spermidine, Polydatin and NADH. Vitamin C, Zinc and Selenium contribute to the protection of cells from oxidative stress, while Griffonia is useful for controlling hunger.

€ 55,92 € 69,90
Abbonati e risparmia: 25% di sconto

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Spermidine, NADH and Polydatin Supplement

Autofagia from the Salugea Longevity line is the new Salugea supplement that combines, in a single formula, natural Spermidine from wheat germ, highly bioavailable Polydatin (a precursor of Resveratrol) and NADH, together with 5-HTP from Griffonia, Vitamin C from Rosehip, and Zinc and Selenium in organic form.

An innovative formula to promote cell renewal!

With Autofagia Salugea you take natural ingredients suitable for supporting the physiological autophagic processes, the mechanisms by which cells “self-recycle” to renew themselves, stay efficient and promote their wellbeing over time.

Its formula brings together 100% natural ingredients that support:

  • cellular regulation;
  • the function of the mitochondria, which are the cells’ energy powerhouses;
  • the activation of sirtuins, key proteins in the biological processes linked to cellular longevity.

The formula is also designed for those following a dietary regime of calorie restriction or intermittent fasting under the guidance of a nutritionist, in order to further encourage the natural process of cellular autophagy, keep hunger under control thanks to the Griffonia, and support energy metabolism thanks to the other natural ingredients.

 

The active ingredients come from bio-fermentation and plant sources (not synthetic!) to offer optimal bioavailability and absorption[1]. Each bottle is made of dark pharmaceutical-grade glass and has a reusable safety seal under the cap, to preserve the quality of the formula down to the very last capsule.

All this with no synthetic colourings, preservatives or sweeteners, because every Salugea product is designed to be truly 100% natural. What’s more, the active ingredients in Autofagia combine and work synergistically, for a broad action that promotes natural cellular wellbeing over time.

Who the Spermidine, NADH and Polydatin formula is for

The 100% natural formula of Autofagia Salugea is suitable for those who:

  • are looking for a new-generation 100% natural supplement of Spermidine, NADH and Polydatin with a high content of natural active ingredients;
  • want to support physiological autophagic processes, thereby supporting cell renewal and wellbeing;
  • are interested in longevity and biohacking and want to take targeted action on long-term cellular maintenance;
  • follow intermittent fasting or calorie restriction programmes and want an ally to support cellular autophagy processes;
  • want to support nervous system wellbeing and cognitive function, especially during periods of mental effort or stress;
  • are looking for energy and tonic support when feeling tired, thanks to its support for mitochondrial function;
  • do sport and want to promote performance, endurance and physiological recovery.

The benefits you get from Autofagia Salugea

Thanks to the 100% natural ingredients in Autofagia Salugea, you provide targeted support for autophagic processes, cellular longevity and your body’s sense of vitality.

Here’s what you can get from this innovative formula:

  • you support natural autophagic processes: Spermidine from wheat germ promotes the physiological process of cellular “self-recycling”[2];
  • you support sirtuins and the mechanisms of longevity: highly bioavailable Polydatin[3] – a molecule considered a precursor of Resveratrol – and NADH[4] contribute to the activity of sirtuins, molecules involved in regulating ageing, metabolism and cell repair processes;
  • you get anti-ageing support: NAD and Spermidine are being studied for their many benefits, which may also involve the signs of ageing[5]. Vitamin C supports Collagen formation;
  • you promote mitochondrial function and vitality: NADH is an essential cofactor for the production of ATP[6], the primary source of cellular energy. In this way you support your mitochondria and, also thanks to the Griffonia, counteract tiredness, fatigue and energy dips caused by stress or a hectic pace of life, supporting mental wellbeing;
  • you counteract oxidative stress and support your defences: natural vitamin C, and Zinc and Selenium in organic forms, contribute to counteracting the harmful action of free radicals and support normal immune defences;
  • you can complement specific dietary regimes: Griffonia extract standardised to 5-HTP can help regulate hunger and mood[7]-[8]. The formula is useful alongside dietary regimes such as calorie restriction, intermittent fasting and the sirt diet, which in turn promote cellular autophagy[9];
  • you promote complete cellular wellbeing: all the active ingredients in Autofagia Salugea work in synergy to support autophagy, the activation of sirtuins, mitochondrial function and protection against oxidative stress.

Why choose Autofagia Salugea as your Spermidine and NADH supplement

Because Autofagia Salugea goes “beyond”, with a multi-action formula designed to work on several levels of cellular wellbeing: autophagic processes, energy, regulation and longevity.

Here’s what makes its formula special: 

  • it is 100% natural: you’ll only find active ingredients of plant origin and from bio-fermentation;
  • it ensures a high content of natural active ingredients;
  • it contains Spermidine from wheat germ, a natural, regulation-compliant source, unlike the synthetic forms that are widespread on the market;
  • it provides NADH from bio-fermentation (PANMOL® NADHmicro), in a microencapsulated, highly bioavailable form;
  • it uses Polydatin, the glycosylated form of Resveratrol, which is more stable and better absorbed, belongs to the polyphenol class and is extracted from the roots of Polygonum;
  • it includes 5-HTP from Griffonia, to help control hunger and maintain a normal mood, useful in combination with intermittent fasting or calorie restriction regimes;
  • it is completed by Zinc and Selenium in the form of organic salts, essential cofactors for the regulation of enzymatic processes, together with Vitamin C from Rosehip, for a broad action against oxidative stress;
  • Autofagia Salugea comes in bottles made of dark pharmaceutical-grade glass, the only material that can guarantee purity, stability and quality down to the very last capsule;
  • the openable vegetable capsules make it easy to take, even for those who have difficulty swallowing;
  • it contains no lactose, colourings, flavourings, preservatives or sweeteners of synthetic origin.

How the formula of Autofagia Salugea, a Spermidine and NADH supplement, works

Autofagia Salugea brings together in a single formulation natural Spermidine from wheat germ, highly bioavailable Polydatin and microencapsulated NADH from bio-fermentation, along with 5-HTP from Griffonia, Zinc, Selenium and Vitamin C from Rosehip. 

A synergy of selected active ingredients to support physiological autophagic processes, renewal and the mechanisms underlying cellular longevity[10].

Natural Spermidine from wheat germ: autophagic processes and longevity

Spermidine is considered a true geroprotector2, meaning a substance able to support the biological processes linked to cellular longevity. It is described in this way because of its ability to promote the mechanisms that preserve cell efficiency over time, such as autophagy.

In Autofagia Salugea Spermidine comes exclusively from wheat germ, a natural plant source. This choice sets it apart from many forms on the market, which are often of synthetic origin, and do not reflect the same quality or regulatory compliance.

One of its most important roles is to support physiological autophagic processes, the natural “self-cleaning” of cells that allows damaged components to be removed and new, functional structures to be regenerated.

Several studies 2-[11]-[12] have associated higher levels of Spermidine with indicators of vitality and general wellbeing, as well as with an action on the cellular ageing process and on age-related conditions[13].

Microencapsulated NADH from bio-fermentation: energy, activity on Sirtuins and redox action

NADH is an essential cofactor for the production of ATP4, the main source of energy for cells. It is the active form of vitamin B3 (Niacin) and the “reduced” version of NAD+, with which it alternates in oxidation-reduction reactions[14].

This means it can counteract the formation and build-up of free radicals, molecules that can interfere with normal biological processes, allowing cells to function efficiently.

In Autofagia Salugea it is present as PANMOL® NADHmicro, obtained through bio-fermentation and enclosed in a microcapsule that protects it from gastric degradation and keeps it stable and more easily absorbed[15]. Free NAD, on the other hand, can be unstable and, because of its size and positive charge (+), may have difficulty crossing cell membranes.

It is also important for the activity of sirtuins, proteins involved in the processes linked to cellular longevity.

Highly bioavailable Polydatin: for an action on sirtuins

Polydatin is the natural precursor of Resveratrol and its most stable and bioavailable form, thanks to its glycosylated structure, which facilitates its absorption and cellular transport. It is extracted from the root of Polygonum cuspidatum, a plant rich in polyphenols and one of the richest natural sources of Polydatin.

Resveratrol is known for supporting the activity of sirtuins and contributing to the protection of cells from oxidative stress, two fundamental aspects of longevity processes.

Studies suggest that Resveratrol can increase levels of SIRT1, one of the sirtuins most involved in cell renewal processes[16]-[17].

5-HTP from Griffonia simplicifolia: also useful alongside dietary regimes

5-HTP is a serotonin precursor obtained from Griffonia, a plant known to contribute to hunger control and to the maintenance of a normal mood.

In contexts such as intermittent fasting or calorie restriction, two conditions that naturally promote autophagy, it can be a valuable ally in supporting mental wellbeing.

The Griffonia used is standardised to 25% 5-HTP, which guarantees a reliable and consistent content of the active ingredient.

Natural Vitamin C from Rosehip: for antioxidant action

Vitamin C has an antioxidant action and therefore helps counteract oxidative stress, a condition that can promote premature cellular ageing[18]. Vitamin C also counteracts the feeling of tiredness and supports both Collagen production and the body’s natural defences.

Like NADH, Vitamin C is also an electron donor, giving up electrons to free radicals in order to neutralise them.

The vitamin C in Autofagia Salugea comes from Rosehip, a natural source rich in this valuable antioxidant.

Zinc in organic form: an essential co-factor

Zinc in bisglycinate form plays an important role in regulating enzyme activity.

It is a cofactor of histone deacetylases (HDAC), enzymes also involved in mechanisms linked to autophagy and to the modulation of gene expression.

Bisglycinate is an organic form that offers higher bioavailability than inorganic forms.

Selenium in organic form: co-factor and antioxidant

Selenium contributes to the normal function of the immune system and has an important antioxidant action. In Autofagia Salugea it is present in organic form for optimal absorption.

Adequate levels of Selenium have been associated with greater activity of sirtuins[19]-[20], proteins involved in longevity processes.

By supporting cellular redox balance, it can help create an environment favourable to autophagy mechanisms.

For optimal supplementation we recommend taking 2 capsules a day, always away from meals.

In particular:

  • Mid-morning: 1 capsule of Autofagia Salugea
  • Mid-afternoon: 1 capsule of Autofagia Salugea

They are vegetable capsules and, to encourage better absorption of the active ingredients, it is preferable to take them two hours away from the main meals.

They can also be opened, making the product easier to take for anyone who has difficulty swallowing capsules whole.

Length of the course with Autofagia Salugea

You may notice positive sensations right from the first doses.
To encourage a more stable and lasting result, we recommend taking the product for at least three consecutive months. 

At the end of the course get in touch!

We are interested to know how you got on: with our experts you will be able to assess together how to carry on in order to maintain and consolidate the benefits obtained.

Warnings

Food supplements are not to be regarded as substitutes for a varied and balanced diet and a healthy lifestyle. Keep out of the reach of children under 3 years of age. Do not exceed the recommended daily dose. The expiry date shown refers to the product when intact, stored in a cool, dry place away from sources of light and heat.

Extract of wheat germ (Triticum aestivum L.) rich in Spermidine, Hydroxypropyl methylcellulose capsule, Rosehip (Rosa canina L.) pseudo-fruit d.e. std. 70% vitamin C, Griffonia (Griffonia simplicifolia Baill.) seeds d.e. std. 25% 5-HTP, Fallopia japonica (Houtt.) Ronse Decr. root d.e. std. 98% Polydatin, PANMOL® NADHmicro (vegetable fats, beeswax, chlorophyll, NADH), Zinc bisglycinate, Selenium L-Methionine, Silica from Bamboo shoots, Anti-caking agent: Vegetable magnesium stearate. The dry extracts are carried on maltodextrin.

AVERAGE AMOUNTS OF NUTRIENTS AND PLANT EXTRACTS IN A DAILY DOSE (2 Capsules)

 

 

 

Wheat germ extract

500 mg

 

equal to Spermidine

1 mg

 

Rosehip d.e. std.

150 mg

 

equal to Vitamin C

105 mg

130% NRV

Griffonia d.e. std.

100 mg

 

equal to 5-HTP

25 mg

 

Fallopia d.e. std.

51 mg

 

equal to Polydatin

50 mg

 

PANMOL® NADHmicro

50 mg

 

equal to NADH

5 mg

 

Zinc

5 mg

50% NRV

Selenium

41 µg

75% NRV

Does it contain gluten?

The wheat germ extract contains the allergen gluten.

Autofagia Salugea was created for those who want to support physiological autophagic processes with a natural approach and an eye on the mechanisms of longevity. It is an increasingly common need, and one that Salugea chose to meet with its own quality and ethical standards.

In a single formula you’ll find natural Spermidine from wheat germ, microencapsulated NADH from bio-fermentation and highly bioavailable Polydatin. These are three active ingredients recognised for their role in the processes of cell renewal, mitochondrial energy and sirtuin support.

The decision to use only natural active ingredients, avoiding the synthetic forms that are widespread on the market (as is the case with many Spermidine products and with NR, or Nicotinamide Riboside), reflects Salugea’s focus on purity, quality and bioavailability. 

The formula is completed by 5-HTP from Griffonia, Vitamin C from Rosehip, and Zinc and Selenium in organic form. These ingredients were all selected to work in synergy and support the body in its natural processes of balance and maintenance of cellular function.

Experimental Phytotherapy

Spermidine

  • Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F.
    Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging. 2022;2(12):1112-1129. doi:10.1038/s43587-022-00322-9.

This study, published in Nature Aging, analyses the mechanisms through which Spermidine supports the processes of autophagy and the phenomena associated with geroprotection.
The authors highlight how this molecule, ubiquitous and naturally present in many foods, is attracting growing scientific interest for its possible role in supporting the cellular processes linked to physiological ageing.

  • Kiechl, S., Pechlaner, R., Willeit, P., et al. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371–380. https://doi.org/10.1093/ajcn/nqy102.

The Bruneck study, published in the American Journal of Clinical Nutrition, followed 829 adults for 20 years, also assessing their dietary intake of Spermidine through dedicated nutritional questionnaires. The analysis showed that those who consumed higher amounts of Spermidine in their diet had favourable indicators in terms of longevity.

The study therefore suggests a possible link between a Spermidine-rich diet and maintaining vitality over time, highlighting the growing interest in this natural compound in the field of wellbeing and cellular longevity.

  • Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4. PMID: 30388439. 

In this clinical study of adults aged between 60 and 80 with cognitive deficits, three months of supplementation with a Spermidine-rich extract showed a positive effect on memory performance compared with placebo. The result suggests a possible role for Spermidine in supporting cognitive function.

NADH

  • Walker MA, Tian R. NAD(H) in mitochondrial energy transduction: implications for health and disease. Curr Opin Physiol. 2018 Jun;3:101-109. doi: 10.1016/j.cophys.2018.03.011. Epub 2018 Apr 11. PMID: 32258851; PMCID: PMC7112453. 

This paper describes how the NAD+/NADH ratio is fundamental to the work of the mitochondria, which produce ATP, the main form of energy for cells.
The authors explain that the amount of NAD+/NADH present in the cell regulates the rate at which mitochondria produce energy, by controlling various enzymes involved in metabolic processes.

  • Srivastava S. Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med. 2016 Dec;5(1):25. doi: 10.1186/s40169-016-0104-7. Epub 2016 Jul 27. PMID: 27465020; PMCID: PMC4963347.

This study describes NADH as the main electron donor in the mitochondrial respiratory chain, an important step in producing ATP, the main form of cellular energy. The authors report that the NAD+/NADH ratio regulates many metabolic processes and that an imbalance in it can affect mitochondrial function and the balance of the cell. The study also suggests that NAD+ is used by sirtuins, which regulate various processes linked to metabolism and physiological cellular ageing.

  • Campbell JM. Supplementation with NAD+and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients. 2022 Aug 7;14(15):3231. doi: 10.3390/nu14153231. PMID: 35956406; PMCID: PMC9370773.

According to this review, raising NAD+ levels through its precursors is considered a promising approach to supporting cognitive abilities during ageing. The authors report encouraging results on the role of NAD+ in supporting processes linked to memory and brain wellbeing, while stressing the need for further clinical studies to better define its potential.

Polydatin

  • Sun Z, Wang X, Xu Z. SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor. Biomed Pharmacother. 2021 Jul;139:111549. doi: 10.1016/j.biopha.2021.111549. Epub 2021 Apr 23. PMID: 33901876.

This review describes Polydatin as a natural compound able to interact with the sirtuin family, particularly SIRT1, which is considered an important regulator of cellular processes linked to metabolism, the stress response and physiological ageing. The authors also suggest that SIRT1 acts as a “metabolic sensor”, pointing to a possible role for Polydatin in supporting the mechanisms that help maintain cellular function over time. 

  • Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014 Mar;35(3):146-54. doi: 10.1016/j.tips.2013.12.004. Epub 2014 Jan 16. PMID: 24439680; PMCID: PMC3970218.
  • Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. PMID: 29577959; PMCID: PMC6342514.

These studies explore the role of Resveratrol as a natural sirtuin activator (STAC), with particular reference to SIRT1, a protein that regulates various cellular processes linked to metabolism, the stress response and the physiological phenomena of ageing. The authors highlight that the modulation of SIRT1 by Resveratrol is one of the most studied mechanisms for explaining its effects on cellular activity.

Griffonia

  • Halford JC, Harrold JA, Lawton CL, Blundell JE. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets. 2005 Mar;6(2):201-13. doi: 10.2174/1389450053174550. PMID: 15777190.

This review highlights the role of serotonin (5-HT) in appetite control, particularly in the mechanisms of satiety during and after meals. The authors suggest that increasing the availability of 5-HT, as happens with 5-HTP, the natural precursor of serotonin, can help reduce appetite and calorie intake by modulating the receptors involved in the feeling of satiety.

Zinc

  • Zheng W. The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation. Mini Rev Med Chem. 2022;22(19):2478-2485. doi: 10.2174/1389557522666220330144151. PMID: 35362374.

This review describes how certain regulatory proteins in the cell, the zinc-dependent HDACs, specifically require Zinc in order to function properly.
The paper therefore highlights the role of Zinc as an essential cofactor for the proper functioning of various cellular pathways involved in maintaining cellular balance.

Selenium

  • Giacconi R, Chiodi L, Boccoli G, Costarelli L, Piacenza F, Provinciali M, Malavolta M. Reduced levels of plasma selenium are associated with increased inflammation and cardiovascular disease in an Italian elderly population. Exp Gerontol. 2021 Mar;145:111219. doi: 10.1016/j.exger.2020.111219. Epub 2020 Dec 26. PMID: 33373712.

In this study, Selenium deficiency was associated with higher levels of inflammatory markers and, above all, with reduced expression of several sirtuins (SIRT1, SIRT5, SIRT6 and SIRT7) in blood cells. Since sirtuins are involved in the processes of metabolic balance, stress response and maintenance of cellular function, the researchers suggest that an adequate intake of Selenium may help support their normal functioning.

Autofagia Salugea is a food supplement: read the warnings on the label. Supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. These texts are for information purposes only; they should not be taken as guidance for the diagnosis or treatment of medical conditions and do not replace your doctor’s advice.

Bibliography

[1] Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004 Dec 16;432(7019):829-37. doi: 10.1038/nature03194. PMID: 15602548.

[2] Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Mechanisms of spermidine-induced autophagy and geroprotection. Nat Aging. 2022 Dec;2(12):1112-1129. doi: 10.1038/s43587-022-00322-9. Epub 2022 Dec 22. PMID: 37118547.

[3] Sun Z, Wang X, Xu Z. SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor. Biomed Pharmacother. 2021 Jul;139:111549. doi: 10.1016/j.biopha.2021.111549. Epub 2021 Apr 23. PMID: 33901876

[4] Madsen, A. S. et al. Investigating the sensitivity of NAD+-dependent sirtuin deacylation activities to NADH. J. Biol. Chem. 291, 7128–7141

[5] Ni YQ, Liu YS. New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases. Aging Dis. 2021 Dec 1;12(8):1948-1963. doi: 10.14336/AD.2021.0603. PMID: 34881079; PMCID: PMC8612618.

[6] Walker MA, Tian R. NAD(H) in mitochondrial energy transduction: implications for health and disease. Curr Opin Physiol. 2018 Jun;3:101-109. doi: 10.1016/j.cophys.2018.03.011. Epub 2018 Apr 11. PMID: 32258851; PMCID: PMC7112453.

[7] Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004. PMID: 16846858.

[8] Halford JC, Harrold JA, Lawton CL, Blundell JE. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets. 2005 Mar;6(2):201-13. doi: 10.2174/1389450053174550. PMID: 15777190.

[9] Bagherniya M, Butler AE, Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: A review of the literature. Ageing Res Rev. 2018 Nov;47:183-197. doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30. PMID: 30172870.

[10] Hansen, M., Rubinsztein, D.C. & Walker, D.W. Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol 19, 579–593 (2018). https://doi.org/10.1038/s41580-018-0033-y

[11] Madeo F, Carmona-Gutierrez D, Kepp O, Kroemer G. Spermidine delays aging in humans. Aging (Albany NY). 2018 Aug 6;10(8):2209-2211. doi: 10.18632/aging.101517. PMID: 30082504; PMCID: PMC6128428.

[12] Hofer, S.J., Daskalaki, I., Bergmann, M. et al. Spermidine is essential for fasting-mediated autophagy and longevity. Nat Cell Biol 26, 1571–1584 (2024). https://doi.org/10.1038/s41556-024-01468-x

[13] Kiechl, S., Pechlaner, R., Willeit, P., et al. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371–380. https://doi.org/10.1093/ajcn/nqy102

[14] Srivastava S. Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med. 2016 Dec;5(1):25. doi: 10.1186/s40169-016-0104-7. Epub 2016 Jul 27. PMID: 27465020; PMCID: PMC4963347.

[15] Vis Vitalis - "Stability of PANMOL®️ NADH in simulated gastric fluid conditions" - https://www.harnisch-digital.de/viitalstoffe-1-2024/68698255/48

[16] Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol Ther. 2018 Aug;188:140-154. doi: 10.1016/j.pharmthera.2018.03.004. Epub 2018 Mar 22. PMID: 29577959; PMCID: PMC6342514.

[17] Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci. 2014 Mar;35(3):146-54. doi: 10.1016/j.tips.2013.12.004. Epub 2014 Jan 16. PMID: 24439680; PMCID: PMC3970218

[18] Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018 Apr 26;13:757-772. doi: 10.2147/CIA.S158513. PMID: 29731617; PMCID: PMC5927356.

[19] Giacconi R, Chiodi L, Boccoli G, Costarelli L, Piacenza F, Provinciali M, Malavolta M. Reduced levels of plasma selenium are associated with increased inflammation and cardiovascular disease in an Italian elderly population. Exp Gerontol. 2021 Mar;145:111219. doi: 10.1016/j.exger.2020.111219. Epub 2020 Dec 26. PMID: 33373712

[20] Shengyu C, Yinhua L, Yuanhong L, Jinbo Z, Can F, Hao X, Changjiang Z. Selenium alleviates heart remodeling through Sirt1/AKT/GSK-3β pathway. Int Immunopharmacol. 2022 Oct;111:109158. doi: 10.1016/j.intimp.2022.109158. Epub 2022 Aug 18. PMID: 35987147.

 

Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.

Italian Ministry of Health code:  203812

Food supplement: read the warnings on the label.
Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.

Confronto

Standard Salugea Standard di mercato
Pharmaceutical-grade dark glass bottle ✓ ❌
High content of active ingredients ✓ ❌
Vegetable capsules ✓ ❌
100% natural and pure ✓ ❌
Standardised dry extracts only ✓ ❌

What you won’t find in our formulations

Our idea of 100% natural also includes what we choose not to use.

No GMOs
No Synthetic Additives
No Plastic
No Artificial Sweeteners
No Lactose
No Synthetic Preservatives

Frequently Asked Questions about the Product

Autofagia Salugea is formulated with 100% natural ingredients to support the physiological processes of autophagy and the mechanisms of longevity. The active ingredients work in synergy to support energy, a feeling of vitality and cellular wellbeing.

Yes. The formula is designed to support the normal process of autophagy, including in those who follow calorie-restriction or intermittent-fasting eating plans, thanks to the presence of 5-HTP from Griffonia, which helps control the feeling of hunger, and to the active ingredients that support energy metabolism.

Of course, Autofagia can be combined with the other Salugea supplements. This way you will work on several needs at the same time. If you have any doubts about taking more than one, contact our experts!

More questions?

If you haven't found the answer to your question, you can contact us:

Call us

Call the Salugea Freephone number
800-688-801 (Mon-Fri)

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Safe, 100% Natural Food Supplements

Free Shipping

Always free shipping: get your supplements delivered straight to your door!

100% Natural, made in-house

Effective formulations, with a high content of active ingredients

Free consultation

Book an appointment with an Expert on the Freephone number: 800-688-801

Secure Payments, Instalments Available

By Credit Card, Satispay, PayPal (including instalments), Bank Transfer or Cash on Delivery

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