Up to 40% of Italians suffer, at least occasionally, from IBS, i.e. irritable bowel syndrome. In practice, almost one person in two.
This estimate, drawn up by the Italian Society of Gastroenterology, is a very striking figure.
Irritable bowel syndrome is a physical disorder which, however, also has major repercussions on mood and quality of life.
Let's see why.
People suffering from IBS experience:
- painful abdominal discomfort, at least once a week over the last three months,
- sudden pangs that lead to bouts of diarrhoea,
- alternating diarrhoea and constipation,
- discomfort that eases after going to the toilet.
The above symptoms have a high impact on the individual's daily life, both physically and emotionally. In fact, people suffering from IBS:
- feel constant apprehension when away from home,
- limit their diet to a few carefully chosen foods,
- need to know whether there is a toilet wherever they are going,
- feel discouraged and low on energy,
- try everything, with little to show for it.
And what are the solutions the market suggests?
Most of the products on the market focus solely on blocking the urge to evacuate. But this solution is only temporary and, over time, will make the discomfort even more intense.
Even taking lactic acid bacteria or probiotics at this stage is of no real help, because if the gut mucosa is irritated the good bacterial strains will not be able to develop properly, as the terrain that is meant to host them is not in a condition to do so.
A correct phytotherapeutic approach should:
- help the intestine regain its physiological motility,
- provide the intestine walls with a lining that protects them,
- control intestinal hyper- or hypomotility,
- support the regeneration of the gut mucosa,
- also take into account the emotional and stress-related side.
This philosophy gave rise to Intestinum Forte, whose natural active ingredients do not merely modulate the enteric stimulus but allow the gut mucosa to regenerate and its motility to return to normal.
All this while also taking the emotional side into account, an essential aspect given that body, mind and environment form an ever more closely connected whole.
Experimental Phytotherapy
Mallow
- Mousavi SM et al. A Review on Health Benefits of Malva sylvestris L. Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Applications. Evidence Based Complement Alternat Med. 2021 Aug 14; 2021: 5548404. doi: 10.1155 / 2021/5548404. PMID: 34434245; PMCID: PMC8382527.
A review of various studies on the different uses and benefits of Mallow, highlighting its antimicrobial, epithelium-protective and antioxidant properties.
- Seddighfar M, Mirghazanfari SM, Dadpay M. Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris, Carum carvi or Medicago sativa, and their combination in a rat model. J Integr Med. 2020 Mar; 18 (2): 181-188. doi: 10.1016 / j.joim.2020.02.003. Epub 2020 Feb 7. PMID: 32113847.
In this study, the researchers focused on the analgesic properties of Mallow. The study was carried out on animals and, given the positive results, the researchers concluded that Mallow can be extremely useful as an analgesic and as an aid in controlling intestinal discomfort.
Perilla
- Ahmed HM. Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt. Molecules. 2018 Dec 28; 24 (1): 102. doi: 10.3390 / molecules24010102. PMID: 30597896; PMCID: PMC6337106.
In this review, the researchers present an overview of Perilla from a botanical, phytochemical and biological point of view. The properties of Perilla were also analysed, in particular its antioxidant content and its antimicrobial, anti-allergic, antidepressant and neuroprotective capacity.
- Urushima H, Nishimura J, Mizushima T, Hayashi N, Maeda K, Ito T. Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1; 308 (1): G32-41. doi: 10.1152 / ajpgi.00294.2014. Epub 2014 Oct 30. PMID: 25359539.
This study analysed the analgesic and soothing effects of Perilla in cases of colitis. The research was carried out on mice and, at the end of the research period, the scientists found a significant improvement in the levels of cytokines, the inflammatory molecules. The researchers conclude that Perilla may be useful in the treatment and prevention of colitis.
Griffonia
- Keszthelyi D. et al. Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome. Aliment Pharmacol Ther. 2014 Aug; 40 (4): 392-402. doi: 10.1111 / apt.12842. Epub 2014 Jun 18. PMID: 24943480.
In this study, the researchers examined how irritable bowel syndrome (IBS) alters serotonin metabolism and how restoring it can also promote gut wellbeing. The research involved 15 people with IBS and 15 healthy people, and was carried out double-blind. At the end of the study, the researchers highlighted that serotonin can strengthen the intestinal barrier and that this effect would be even more marked and positive in subjects with IBS.
- Garvin B, Wiley JW. The role of serotonin in irritable bowel syndrome: implications for management. Curr Gastroenterol Rep. 2008 Aug; 10 (4): 363-8. doi: 10.1007 / s11894-008-0070-3. PMID: 18627647.
In this review, the researchers analysed the role of serotonin in irritable bowel syndrome. In particular, it addresses the evidence that IBS is associated with alterations in serotonin metabolism, a very important aspect to bear in mind in order to explain and treat IBS.
Star Anise
- Xing JF, Sun JN, Sun JY, You CY, Dong K, Lv J, Dong YL. Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats. Dig Dis Sci. 2012 Aug; 57 (8): 2045-54. doi: 10.1007 / s10620-012-2155-y. Epub 2012 Apr 3. PMID: 22476587 .
In this study, the researchers investigate the effects and mechanism of Star Anise in cases of colitis in rats. At the end of the study, the scientists found a significant improvement both in the colitis itself and, in particular, in the tissues of the colon involved in this problem.
- Wang GW, Hu WT, Huang BK, Qin LP. Illicium verum: a review on its botany, traditional use, chemistry and pharmacology. J Ethnopharmacol. 2011 Jun 14; 136 (1): 10-20. doi: 10.1016 / j.jep.2011.04.051. Epub 2011 Apr 29. PMID: 21549817.
A review of the botany, traditional uses, chemistry and pharmacology of Star Anise. The researchers highlighted how Star Anise was already used in ancient times in Chinese Medicine to regulate the flow of Qi and relieve pain. The review then analysed modern studies which confirmed the earlier ones and added the antimicrobial, antioxidant, insecticidal, analgesic, sedative and convulsive properties of Star Anise.
DISCLAIMER
N.B. Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.
Our texts are for information purposes only; they are not to be understood as an indication for the diagnosis and treatment of medical conditions and are in no way intended to replace the advice of a doctor.