For maximum benefits, we recommend that you take two capsules of Diuresan Potentiated Formula daily.

Specifically:

• Mid-morning, away from meals*: one capsule of Diuresan Formula Potenziata
• Mid-afternoon, away from meals*: one capsule of Diuresan Formula Potenziata.

*By "away from meals" we mean one hour after the last meal or one hour after the next meal.

Note: If you experience heaviness in your stomach when you ingest the capsules on an empty stomach, we recommend taking the product together with a small bite (fruit, yogurt, galette, seeds, etc.).

Duration of treatment with Diuresan Formula Potenziata, a diuresis supplement

Already after a few days you will be able to see the benefits. We recommend that you continue the treatment for three months to consolidate and maintain the results obtained over time.

Each time you finish a month of treatment we suggest you take a break of two to three days before starting the next month. This short break is not mandatory, but serves to make the treatment even more effective over time!

At the end of the third month, you can repeat the treatment (to achieve even more results) or switch to the maintenance phase.

Maintenance phase

Take one capsule a day away from meals, maintaining the 2/3-day breaks between one month and the next.

If you like, at the end of the treatment, give us a call! We are interested in you and want to know how you found yourself.

Together with our experts, you will understand how to approach the next period to maintain your results!

N.B. Each person is unique and can adjust or modify the dosages according to their needs. Just call or email us with any questions or needs. Our experts are at your disposal ;)

Already by itself Diuresan Potentiated Formula gives you excellent results. If you want to make its action even more complete you can combine it with:

• Biosnel Potentiated Formula with specific active ingredients to combat cellulite imperfections;
• Venasal with specific actives to support venous circulation and act on prominent veins and capillaries;
• Maqui Juice Bio First Quality for maximum supply of antioxidants;
• Sanuril Formula Potenziata for all-around urinary tract wellness.

Warnings

Supplements are not intended as a substitute for a varied and balanced diet. Keep out of reach of children under 3 years of age. Do not exceed the recommended dose. The expiration date indicated refers to the unopened product, stored in a cool, dry place and away from light and heat sources.

Pilosella (Hieracium pilosella L.) herb d.s. tit. 1% vitexin, Birch (Betula pubescens Ehrh.) leaves d.s. tit. 2.5% hyperoside, Hydroxypropyl methylcellulose capsule, Orthosiphon (Orthosiphon stamineus Benth) leaves d.s. tit. 0.2% synensetin, Ash (Fraxinus excelsior L.) leaves d.e. tit. 2% chlorogenic ac, Hibiscus (Hibiscus sabdariffa L.) flower d.e. tit. 2% anthocyanins, Anti-caking agents: Silicon dioxide, Vegetable magnesium stearate. Extracts are supported on maltodextrins.

Nutritional Inputs of Diuresan

Water retention is not just the body's tendency to retain excess fluids. More precisely, we can define it as the tendency of cells to retain fluids, toxins and salts ^[4].

When cells fail to get rid of the wastes they produce-for example, toxins, salts, and uric acids-the concentration of the latter increases.

This stagnation of toxins leads to increased interstitial fluids between cells. And so water retention is generated, which manifests as the connective swelling that in medical terms is called edema ^[5].

Unlike cellulite, water retention is not just a female problem. Men can suffer from it as well. But even though (for once) an even aesthetic disorder can affect men as well, it is still women who accuse more ^[6].

There are several causes that can lead to these annoyances. For ^example5:

• sedentariness or conversely too much time standing,
• diet rich in sugar, salt and alcohol,
• dehydration,
• hormonal imbalances or specific times in a woman's life such as, pregnancy and menopause,
• high blood pressure,
• intake of medications.

Over the years, phytotherapy has increasingly studied these conditions, and studies testifying to the importance of even a natural approach are several.

In the next section, we will look at some of them and understand how it is why plant actives can be useful to promote diuresis and help you get rid of excess fluids and toxins.

Experimental Phytotherapy

The formulation of Diuresan Potentiated Formula includes Pilosella, Birch, Orthosiphon, Ash and Hibiscus.

Let us now look at in-depth studies conducted on these actives.

Pilosella

• Stanojević L, Stanković M, Nikolić V, Nikolić L, Ristić D, Canadanovic-Brunet J, Tumbas V. Antioxidant Activity and Total Phenolic and Flavonoid Contents of Hieracium pilosella L. Extracts. Sensors (Basel). 2009;9(7):5702-14. doi: 10.3390/s90705702. Epub 2009 Jul 16. PMID: 22346723; PMCID: PMC3274148.

In this study, researchers showed that Pilosella, in addition to being a strong diuretic, is also a powerful antioxidant.

Birch

• Raudonė L, Raudonis R, Janulis V, Viškelis P. Quality evaluation of different preparations of dry extracts of birch (Betula pendula Roth) leaves. Nat Prod Res. 2014;28(19):1645-8. doi: 10.1080/14786419.2014.925893. Epub 2014 Jun 17. PMID: 24934103.

This study evaluated the effects of different types of Birch showing that it is with dry extracts that the greatest benefits are obtained.

Orthosiphon

• Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. J Med Food. 2012 Aug;15(8):678-90. doi: 10.1089/jmf.2011.1973. Epub 2012 Jun 25. PMID: 22846075.

This review presents a comprehensive summary of the chemical, pharmacological, and toxicological investigations currently available on Orthosiphon. In detail, the researchers found that this plant has diuretic, hypouricemic, renal protective, antioxidant, anti-inflammatory, hepatoprotective, gastroprotective, antihypertensive, antihyperlipidemic, and antimicrobial properties. The researchers conclude that orthosiphon has wide traditional and functional uses in various pathophysiological conditions.

Ash tree

• Younis T, Khan MR, Sajid M, Majid M, Zahra Z, Shah NA. Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies. BMC Complement Altern Med. 2016 Jul 19;16:230. doi: 10.1186/s12906-016-1189-7. PMID: 27430329; PMCID: PMC4949749.

Study demonstrates the therapeutic potential of Algerian or Afghan Ash leaves against inflammatory disorders due to the presence of active constituents in the chloroform fraction.

• Casadebaig J, Jacob M, Cassanas G, Gaudy D, Baylac G, Puech A. Physicochemical and pharmacological properties of spray-dried powders from Fraxinus excelsior leaf extracts. J Ethnopharmacol. 1989 Sep;26(2):211-6. doi: 10.1016/0378-8741(89)90069-x. PMID: 2601362.

This study confirms the major properties of Ash excelsior leaf extracts in body fluid drainage and urinary tract function.

• Younis T, Khan MR, Sajid M, Majid M, Zahra Z, Shah NA. Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies. BMC Complement Altern Med. 2016 Jul 19;16:230. doi: 10.1186/s12906-016-1189-7. PMID: 27430329; PMCID: PMC4949749.

In this research, another characteristic of Ash tree was explored, namely, its pronounced activity against inflammatory disorders as well.

Hibiscus

• Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. - a phytochemical and pharmacological review. Food Chem. 2014 Dec 15;165:424-43. doi: 10.1016/j.foodchem.2014.05.002. Epub 2014 May 27. PMID: 25038696.

This research is a synthesis of other studies that have documented how Hibiscus has, in addition to draining activity, antibacterial, antioxidant, nephro- and hepatoprotective, hypolipidemic (anti-cholesterol) and antihypertensive effects.

• Alarcón-Alonso J, Zamilpa A, Aguilar FA, Herrera-Ruiz M, Tortoriello J, Jimenez-Ferrer E. Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. J Ethnopharmacol. 2012 Feb 15;139(3):751-6. doi: 10.1016/j.jep.2011.12.005. Epub 2011 Dec 13. PMID: 22178178.

In this study, it was shown that the compound found in Hibiscus sabdariffa (or karkadè), quercetin acts on vascular endothelium by causing the release of nitric oxide, which increases renal vasodilation and thus promotes renal filtration. Therefore, the diuretic effect of Hibiscus sabdariffa may be mediated by nitric oxide release.

^[ 1^] July 1, 2014 EMA/HMPC/680373/2013 Committee on Herbal Medicinal Products (HMPC) Assessment report on Hieracium pilosella L., herba (PDF).

^[2] Nat Prod Res. 2014;28(19):1645-8. doi: 10.1080/14786419.2014.925893. Epub 2014 Jun 17. Quality evaluation of different preparations of dry extracts of birch (Betula pendula Roth) leaves. Raudonė L, Raudonis R, Janulis V, Viškelis P.

^[3] Ameer OZ, Salman IM, Asmawi MZ, Ibraheem ZO, Yam MF. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology. J Med Food. 2012 Aug;15(8):678-90. doi: 10.1089/jmf.2011.1973. Epub 2012 Jun 25. PMID: 22846075.

^[4] Humanitas San Pio X - Leg water retention, how to counteract it? - Dr. Massimo Callegari - 04/07/2017.

^[5] Humanitas Gavazzeni - Medical encyclopedia: Water retention.

^[6] Humanitas Research hospital - Symptoms: Water retention.

I nostri testi hanno scopo divulgativo, non vanno intesi come indicazione di diagnosi e cura di stati patologici e non vogliono sostituirsi in alcun modo al parere del Medico.